Title:
細菌におけるプラスミド遺伝の安定化
Document Type and Number:
Japanese Patent JP2004510745
Kind Code:
A
Abstract:
The invention relates to a vaccine comprising a pharmaceutically acceptable carrier or diluent and a bacterium, wherein the bacterium contains (i) a DNA sequence encoding a site-specific recombinase, and (ii) a plasmid comprising a recognition element for the recombinase and a DNA sequence encoding a heterologous polypeptide. The recombinase stabilises inheritance of the plasmid and thereby prevents the bacterium from losing the ability to express the heterologous polypeptide.
Inventors:
Turner, Arthur, Keith
Stevens, Jonathan, Clive
Stevens, Jonathan, Clive
Application Number:
JP2002532247A
Publication Date:
April 08, 2004
Filing Date:
October 02, 2001
Export Citation:
Assignee:
Acumbis Research Limited
International Classes:
A61K39/00; A61K39/04; A61K39/07; A61K39/095; A61K39/10; A61K39/106; A61K39/108; A61K39/112; A61P1/04; A61P31/04; A61P37/02; C12N1/21; C12N15/68; (IPC1-7): A61K39/00; A61K39/04; A61K39/07; A61K39/095; A61K39/10; A61K39/106; A61K39/108; A61K39/112; A61P1/04; A61P31/04
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda