Title:
医薬としてのシクロペンタン誘導体
Document Type and Number:
Japanese Patent JP2004511446
Kind Code:
A
Abstract:
The present invention provides a novel compound represented by the general formula I;wherein R is H or COR3;R1 is H, R2, phenyl, or COR3, wherein R2 is C1-C5 lower alkyl and R3 is R2 or phenyl;Z is CH2 or O;Y is OH or OCOR3;x is 0 or 1; andX is C1-C5 n-alkyl, C3-C7 cycloalkyl, phenyl, furanyl, thienyl or substituted derivatives thereof, wherein the substituents maybe selected from the group consisting of C1-C5 alkyl, halogen, CF3, CN, NO2, NR42, CO2R4 and OR4 wherein R4 is hydrogen or C1-C5 alkyl and dotted lines represent the presence or absence of a double bond and wavy lines represent a cis or trans bond. These novel compounds are especially useful for treating elevated intraocular pressure (ocular hypertension) and glaucoma.
Inventors:
Robert M. Burke
Mark Holoboski
Mari F Postner
Mark Holoboski
Mari F Postner
Application Number:
JP2002529052A
Publication Date:
April 15, 2004
Filing Date:
May 23, 2001
Export Citation:
Assignee:
ALLERGAN,INCORPORATED
International Classes:
A61K31/5575; A61K31/558; A61K31/559; A61P1/00; A61P9/12; A61P13/10; A61P13/12; A61P15/00; A61P19/08; A61P27/06; A61P29/00; A61P35/00; A61P37/02; C07C35/06; C07C69/78; C07C405/00; C07D333/28; C07D333/16; (IPC1-7): C07C405/00; A61K31/5575; A61K31/558; A61K31/559; A61P1/00; A61P9/12; A61P13/10; A61P13/12; A61P15/00; A61P19/08; A61P27/06; A61P29/00; A61P35/00; A61P37/02; C07C35/06; C07C69/78; C07D333/16; C07D333/28
Foreign References:
| EP0002590A1 | 1979-06-27 |
Attorney, Agent or Firm:
Aoyama Aoi
Osamu Kawamiya
Yasuo Shibata
Osamu Kawamiya
Yasuo Shibata