ジスルフィド架橋環化ペプチドを含むワクチン免疫原およびそのアレルギー治療への使用

Japanese Patent JP2004514655

A

The present invention relates to a novel chemical process for the covalent conjugation of disulphide bridge cyclised peptides to immunogenic carrier molecules by thio-ether linkages to form vaccine immunogens. In particular, the novel chemistry involves reacting a thiolated carrier with a cyclic peptide containing a disulphide bridge, which cylcic peptide (herein a disulphide bridge cyclised peptide) has attached to it, usually via a linker, a reactive group capable for forming thio-ether bonds with the carrier. The invention further related to activated peptide intermediates of the process, medicaments produced by the process, pharmaceutical compositions containing the medicaments, and the use of the pharmaceutical compositions in medicine. The process of the present invention is particularly useful for the preparation of highly pure immunogens for vaccines, comprising disulphide bridge cyclised peptides. Also novel immunogens are provided, base don peptides derived from the sequence of human IgE, which are useful in the immunotherapy of allergy. Accordingly, the inventions related also to a process for conjugation of IgE disulphide bridge cyclised peptides to carrier, immunogens produced by the process and vaccines and pharmaceutical compositions comprising them and their use in the treatment of allergy.

Fried, martin
Mason scene
Turnell, william, gordon
Vinals Wy Bassors, Carlota

JP2002521504A

May 20, 2004

August 17, 2001

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GlaxoSmithKline Biologicals Society Anonymous
Acambis Research Limited

A61K39/00; A61K39/385; A61P37/08; C07K1/107; C07K1/22; C07K16/00; C07K16/18; A61K38/00; A61K38/095; (IPC1-7): C07K16/18; A61K39/00; A61P37/08; C07K1/22

Yusuke Hiraki
Satoshi Fujita
Ishii Teiji

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