Title:
インドール誘導体を用いて眼圧を下降させる方法
Document Type and Number:
Japanese Patent JP2004518612
Kind Code:
A
Abstract:
The present invention provides a method of reducing intraocular pressure by administering pharmaceutical compositions comprising indole derivatives. The pharmaceutical compositions useful in this invention comprise indole derivatives and melatonin analogs of Formulae (I) (II) (III) (IV). A preferred embodiment is a method of lowering intraocular pressure using 5-(methoxycarbonylamino)-N-acetyltryptamine (5-MCA-NAT), also known as GR 135531, which has a prolonged duration of action and greater efficacy in lowering intraocular pressure compared to melatonin. The present invention further provides a method of treating disorders associated with ocular hypertension, and a method of treating various forms of glaucoma; the method comprises administering an effective dose of a pharmaceutical composition comprising an indole derivative with or without agents commonly used to treat such disorders.
Inventors:
Pintor, Hessota.
Peral, Maria Ah.
Peterson, Ward M.
Broad, Robert Jr
Brown, Edward G.
Yaza, Benjamin Earl.
Peral, Maria Ah.
Peterson, Ward M.
Broad, Robert Jr
Brown, Edward G.
Yaza, Benjamin Earl.
Application Number:
JP2002515255A
Publication Date:
June 24, 2004
Filing Date:
July 27, 2001
Export Citation:
Assignee:
Inspire Pharmaceuticals, Incorporated
University Complutence de Madrid
University Complutence de Madrid
International Classes:
C07D471/04; A61K9/06; A61K9/08; A61K9/10; A61K9/127; A61K9/14; A61K31/404; A61K31/4045; A61K31/437; A61K31/55; A61K45/00; A61K45/06; A61K47/10; A61P27/02; A61P27/06; C07D209/14; C07D209/16; C07D209/30; (IPC1-7): A61K31/4045; A61K9/06; A61K9/08; A61K9/10; A61K9/127; A61K9/14; A61K31/437; A61K45/00; A61K47/10; A61P27/02; A61P27/06; C07D209/14; C07D209/16; C07D209/30; C07D471/04
Attorney, Agent or Firm:
Takashi Ishida
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji
Jun Tsuruta
Fukumoto product
Masaya Nishiyama
Higuchi Souji