Title:
モノマー転写活性化活性を有するNurr1転写因子I-ボックス変異体
Document Type and Number:
Japanese Patent JP2004519227
Kind Code:
A
Abstract:
The invention relates to the finding that the Nurr1 transciption factor, which forms a heterodimer with the retinoid X receptor, can be mutated in the I box region such that dimerisation does not occur while Nurr1 transcriptional activation activity is retained. The invention provides Nurr1 peptides with such I box mutations, as well as assay methods for modulators which affect the monomeric activity of Nurr1.
Inventors:
Pearlman, thomas
Earl Nissaro, Peer
Earl Nissaro, Peer
Application Number:
JP2002559789A
Publication Date:
July 02, 2004
Filing Date:
January 25, 2002
Export Citation:
Assignee:
LUDWIG INSTITUTE FOR CANCER RESEARCH
International Classes:
C07K14/705; C12N15/12; C12Q1/68; C12Q1/6886; C12N15/09; C12Q1/6897; (IPC1-7): C12N15/09; C07K14/705; C12Q1/68
Attorney, Agent or Firm:
Shuichiro Kitamura