Title:
低減された免疫原性を有する修飾されたインターロイキン-1受容体アンタゴニスト(IL-1RA)
Document Type and Number:
Japanese Patent JP2004519230
Kind Code:
A
Abstract:
The present invention relates to polypeptides to be administered especially to humans and in particular for therapeutic use. The polypeptides are modified polypeptides whereby the modification results in a reduced propensity for the polypeptide to elicit an immune response upon administration to the human subject. The invention in particular relates to the modification of interleukin-1 receptor antagonist (IL-1RA) to result in IL-1RA proteins that are substantially non-immunogenic or less immunogenic than any non-modified counterpart when used in vivo.
More Like This:
Inventors:
Car, Francis, Jay.
Carter, Graham
Jones, Tim
Williams, Stephen
Carter, Graham
Jones, Tim
Williams, Stephen
Application Number:
JP2002562381A
Publication Date:
July 02, 2004
Filing Date:
February 05, 2002
Export Citation:
Assignee:
Merck Patent Gesellschaft mit beschraenkter Haftung
International Classes:
A61K9/70; A61K38/00; A61K38/20; A61K45/00; A61K47/02; A61K47/12; A61P37/00; A61P43/00; C07K7/06; C07K7/08; C12N15/09; C07K14/47; C07K14/54; C07K16/18; C07K16/28; C07K16/30; C07K16/46; C12N15/17; C12P21/02; G16B15/20; G16B20/00; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61P37/00; A61P43/00; C07K7/06; C07K7/08; C07K14/47; C12P21/02
Attorney, Agent or Firm:
Akio Miyazaki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki
Nobuyuki Kaneda
Katsuhiro Ito
Ishibashi Masayuki