Title:
オステオレビン遺伝子多型性
Document Type and Number:
Japanese Patent JP2004520005
Kind Code:
A
Abstract:
The present inventon relates generally to genetic polymorphisms in the Van Buchem-scierosteosis disease region. In particular, the present invention relates to genetic polymorphisms in the Van Buchem-sclerosteosis disease region that are associated with disorders resulting in either net excess bone formation or insufficient bone formation in humans. Furthermore, isolated nucleic acid molecules encoding human osteolevin are provided. Osteolevin polypeptides are also provided as are vectors, host cells and recombinant methods for producing the same.
Inventors:
Vallemans Wendy
Evering Martin
Fauerncheler Dorothy
Patel Neira
Banhal Wim
Bickley Brian Henry
Evering Martin
Fauerncheler Dorothy
Patel Neira
Banhal Wim
Bickley Brian Henry
Application Number:
JP2002504639A
Publication Date:
July 08, 2004
Filing Date:
June 15, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
A61K38/00; A61K45/00; A61P19/08; C07K14/47; C07K14/51; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N15/12; C12P21/02; C12Q1/02; C12N15/09; C12Q1/68; C12Q1/6883; (IPC1-7): C12N15/09; A61K38/00; A61K45/00; A61P19/08; C07K14/51; C07K16/18; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12P21/02; C12Q1/02; C12Q1/68
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Kazunori Hashimoto