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Title:
GnRH拮抗薬の投与による糖尿病の予防
Document Type and Number:
Japanese Patent JP2004521114
Kind Code:
A
Abstract:
A method for reducing the incidence or delaying the onset of diabetes in diabetes-susceptible mammals (e.g., mice, rats, humans) is provided wherein the mammals are treated with a gonadotropin-releasing hormone (GnRH) antagonist. Additionally, the present invention provides a method of prolonging the honeymoon phase and decreasing the rate of islet cell infiltration by lymphocytes by administration of a GnRH antagonist. Preferably, the antagonist is administered repeatedly over time by subcutaneous injection. Preferred antagonists include Acetyl-beta-[2-Naphthyl]-D-Ala-D-p-Chloro-Phe-beta-[3-Pyridyl]-D-Ala-Ser-Nepsilon-[Nicotinoyl]-Lys-Nepsilon-[Nicotinoyl]-D-Lys-Leu-Nepsilon-[Isopropyl]-Lys-Pro-D-Ala-NH2, Nal-Glu, Abarelix, Degarelix, and acetyl-D2Nal-D4CIPhe-D3Pal-Ser-Aph(Ac)-D-Aph(Ac)-Leu-Lys(lpr)-Pro-D-Ala-NH2.

Inventors:
Jacobson Jill Dee.
Application Number:
JP2002559049A
Publication Date:
July 15, 2004
Filing Date:
August 06, 2001
Export Citation:
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Assignee:
The Children's Mercy Hospital
International Classes:
A61K38/08; A61K45/00; A61K38/04; A61K38/09; A61P3/10; C07K7/06; (IPC1-7): A61K45/00; A61K38/04; A61P3/10
Attorney, Agent or Firm:
Nozomi Watanabe
Haruko Sanwa