Title:
エリスロポエチンコンジュゲート
Document Type and Number:
Japanese Patent JP2004525097
Kind Code:
A
Abstract:
The present invention refers to conjugates of erythropoietin with poly(ethylene glycol) comprising an erythropoietin glycoprotein having an N-terminal alpha-amino group and having the in vivo biological activity of causing bone marrow cells to increase production of reticulocytes and red blood cells and selected from the group consisting of human erythropoietin and analogs thereof which have the sequence of human erythropoietin modified by the addition of from 1 to 6 glycosylation sites or a rearrangement of at least one glycosylation site; said glycoprotein being covalently linked to one poly(ethylene glycol) group of the formula -CO-(CH2)x-(OCH2CH2)m-OR wherein the -CO of the poly(ethylene glycol) group forms an amide bond with said N-terminal alpha-amino group; and wherein R is lower alkyl; x is 2 or 3; and m is from about 450 to about 1350.
Inventors:
Burg, Josef
Engel, Alfred
Franze, Reinhard
Hilger, Bernd
Shulig, Hartmut Ernst
Tisher, Wilhelm
Votney, Manfred
Engel, Alfred
Franze, Reinhard
Hilger, Bernd
Shulig, Hartmut Ernst
Tisher, Wilhelm
Votney, Manfred
Application Number:
JP2002551010A
Publication Date:
August 19, 2004
Filing Date:
December 08, 2001
Export Citation:
Assignee:
F. HOFFMANN-LA ROCHE AKTIENGESELLSCHAFT
International Classes:
C12P21/02; A61K47/48; A61P7/06; A61P13/12; A61P31/18; A61P35/00; C07K1/113; C07K14/505; (IPC1-7): C07K14/505; A61K47/48; A61P7/06; A61P13/12; A61P31/18; A61P35/00; C07K1/113; C12P21/02
Attorney, Agent or Firm:
Hajime Tsukuni
Fumio Shinoda
Fumio Shinoda