Title:
シタロプラムの調製方法
Document Type and Number:
Japanese Patent JP2004529883
Kind Code:
A
Abstract:
This invention discloses an improved process for the preparation of citalopram of the formula III which comprises (i) preparing the compound of the formula VIII by reducing an unisolable magnesium salt of a benzophenone derivative of the formula V using sodium borohydride in the presence of a protic solvent, (ii) reacting the compound of the formula VIII obtained in step (i) with an acid catalyst in a non-polar solvent to obtain a compound of the formula I, (iii) reacting the compound of the formula I obtained in step (ii) with copper (I) cyanide in a polar solvent medium and isolating the resulting cyano compound, by recrystallization by using polar and/or alcoholic solvents to obtain the compound of the formula II and (III) reacting the resulting compound of the formula II by conventional methods to form citalopram of the formula III. Citalopram is widely used as an antidepressant.
Inventors:
Pula, Lady, Muddha Sani
Venkaia, Chaudhary, Nanpaneni
Venkaia, Chaudhary, Nanpaneni
Application Number:
JP2002565969A
Publication Date:
September 30, 2004
Filing Date:
February 11, 2002
Export Citation:
Assignee:
Natco Pharma Limited
International Classes:
A61K31/343; A61P25/24; C07B61/00; C07D307/87; (IPC1-7): C07D307/87
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners