Title:
癌・精巣抗原
Document Type and Number:
Japanese Patent JP2004532629
Kind Code:
A
Abstract:
Cancer-testis (CT) antigens have been identified by screening public databases for transcripts that are expressed in tumor tissues and a limited set of normal tissues, or by screening for genes that are expressed in cancer and testis tissues (but not other normal tissues). The invention relates to nucleic acids and encoded polypeptides which are CT antigens expressed in patients afflicted with cancer. The invention provides, inter alia, isolated nucleic acid molecules, expression vectors containing those molecules and host cells transfected with those molecules. The invention also provides isolated proteins and peptides, antibodies to those proteins and peptides and cytotoxic T lymphocytes which recognize the proteins and peptides. Fragments of the foregoing including functional fragments and variants also are provided. Kits containing the foregoing molecules additionally are provided. The molecules provided by the invention can be used in the diagnosis, monitoring, research, or treatment of conditions characterized by the expression of one or more CT antigens.
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Inventors:
Old, Lloyd, Jay.
Scanlan, Matthew, Jay.
Chen, Yao-Tseng
Scanlan, Matthew, Jay.
Chen, Yao-Tseng
Application Number:
JP2002576801A
Publication Date:
October 28, 2004
Filing Date:
March 29, 2002
Export Citation:
Assignee:
LUDWIG INSTITUTE FOR CANCER RESEARCH
Cornell Research Foundation, Inc.
Cornell Research Foundation, Inc.
International Classes:
G01N33/53; A61K31/7088; A61K35/12; A61K38/00; A61K39/00; A61K39/39; A61K39/395; A61K48/00; A61P35/00; A61P35/02; C07K14/47; C07K14/82; C07K16/28; C07K16/30; C07K16/46; C12N15/09; C12P21/08; C12Q1/68; G01N33/566; G01N33/574; G01N37/00; (IPC1-7): C12N15/09; A61K31/7088; A61K35/12; A61K38/00; A61K39/00; A61K39/39; A61K39/395; A61K48/00; A61P35/00; A61P35/02; C07K14/82; C07K16/28; C07K16/46; C12Q1/68; G01N33/53; G01N33/566; G01N37/00
Attorney, Agent or Firm:
Kiyoji Kuzuwa