Title:
オリゴヌクレオチドのinvivoでの効率を増加するおよび哺乳動物において炎症を阻害するための方法
Document Type and Number:
Japanese Patent JP2004532900
Kind Code:
A
Abstract:
The invention relates to the use of nucleotide substitutes for increasing the in vivo efficacy of nucleic acid molecules and also for inhibiting inflammation in mammals. More particularly, the present invention relates to the use of 2′6′ diaminopurine (DAP) and analogs thereof per se in anti-inflammatory compositions, and also for preparing nucleic acid molecules having an increased in vivo physiological efficiency and a reduced toxicity as compared to conventional oligos. The invention is particularly useful for the preparation of antisense oligonucleotides for treating pulmonary/respiratory diseases such as cystic fibrosis, asthma, chronic bronchitis, chronic obstructive lung disease, eosinophilic bronchitis, allergies, allergic rhinitis, pulmonary fibrosis, adult respiratory distress syndrome, sinusitis, respiratory syncytial virus or other viral respiratory tract infection and cancer.
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Inventors:
Renzi, Paolo
Alam, Mustafa
Arkvardy, Soulfir
Alam, Mustafa
Arkvardy, Soulfir
Application Number:
JP2003510677A
Publication Date:
October 28, 2004
Filing Date:
July 08, 2002
Export Citation:
Assignee:
Topigen Farmer Sustic Inc.
International Classes:
C12N15/09; A61K31/7076; A61K31/7115; A61P1/04; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P17/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/12; A61P31/14; A61P35/00; A61P37/02; A61P43/00; C07H19/16; C07H19/23; C07H21/00; C07H21/04; C12N15/113; A61K38/00; (IPC1-7): C07H21/04; A61K31/7115; A61P1/04; A61P9/00; A61P11/00; A61P11/02; A61P11/06; A61P13/00; A61P17/00; A61P25/00; A61P25/28; A61P27/02; A61P29/00; A61P31/00; A61P31/12; A61P31/14; A61P35/00; A61P37/02; A61P43/00; C12N15/09
Foreign References:
| WO2000012563A1 | 2000-03-09 | |||
| WO1999067378A1 | 1999-12-29 | |||
| US3337530A | 1967-08-22 | |||
| WO1999066037A2 | 1999-12-23 |
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa