Title:
α-2B-アドレナリン受容体が介在する疾患を治療又は予防するために有用な化合物
Document Type and Number:
Japanese Patent JP2004535467
Kind Code:
A
Abstract:
The invention relates to compounds of formula (I) or a pharmaceutically acceptable salt thereof wherein R>1<, R>2<, R>3<, R>4< and R>5< are independently of each other H, a straight or branched alkyl or alkoxy group with 1 to 4 carbon atoms, or a halogen; X is H, a straight or branched alkyl chain with 1 to 4 carbon atoms, phenyl, -OH or =O; Z is H, acetyl, -CH>2<-Ph-O-CF>3< or CH>2<-Ph-CF>3<, Y is a ring structure optionally linked to formula (I) with an alkyl chain having one or two carbon atoms. This invention further relates to the use of said compounds for the manufacture of a pharmaceutical preparation useful for the treatment or prevention of a disease mediated by the alpha-2B-adrenoceptor in a mammal.
Inventors:
Yotsusamo, Topi
Taubel, Andrey Yuryevich
Salo, Harry
Hofren, Anna-Maruya
Burster, siegfried
Taubel, Andrey Yuryevich
Salo, Harry
Hofren, Anna-Maruya
Burster, siegfried
Application Number:
JP2003513947A
Publication Date:
November 25, 2004
Filing Date:
July 22, 2002
Export Citation:
Assignee:
Osuke Yuichia Juventia Pharma Limited
International Classes:
A61K31/635; A61K45/00; A61P3/04; A61P9/10; A61P9/12; A61P15/00; A61P15/10; A61P25/02; A61P25/06; A61P43/00; C07D239/42; C07D239/69; C07D401/12; C07D403/12; (IPC1-7): C07D239/69; A61K31/635; A61K45/00; A61P3/04; A61P9/10; A61P9/12; A61P15/00; A61P15/10; A61P25/02; A61P25/06; A61P43/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
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