Title:
P38のイソキノリンインヒビター
Document Type and Number:
Japanese Patent JP2005500284
Kind Code:
A
Abstract:
The present invention relates to inhibitors (Ia-Ib) of p38, a mammalian protein kinase involved cell proliferation, cell death and response to extracellular stimuli. The invention also relates to methods for producing these inhibitors. The invention also provides pharmaceutical compositions comprising the inhibitors of the invention and methods of utilizing those compositions in the treatment and prevention of various disorders. All substituents are as in claim 1.
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Inventors:
Cochrane, John Yee.
Tan, Roger Dee.
Tan, Roger Dee.
Application Number:
JP2003503226A
Publication Date:
January 06, 2005
Filing Date:
June 11, 2002
Export Citation:
Assignee:
VERTEX PHARMACEUTICALS INCORPORATED
International Classes:
A61K31/472; A61K31/4725; A61K31/496; A61K31/551; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D217/18; C07D217/22; C07D217/24; C07D401/04; (IPC1-7): C07D217/22; A61K31/472; A61K31/4725; A61K31/496; A61K31/551; A61P1/00; A61P1/04; A61P1/16; A61P1/18; A61P3/10; A61P7/00; A61P7/02; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P17/00; A61P19/00; A61P19/02; A61P19/10; A61P21/04; A61P25/00; A61P25/16; A61P25/28; A61P29/00; A61P31/00; A61P31/12; A61P31/18; A61P35/00; A61P35/02; A61P37/02; A61P37/06; A61P37/08; A61P43/00; C07D217/24; C07D401/04
Foreign References:
| WO1999064400A1 | 1999-12-16 | |||
| WO1999018077A1 | 1999-04-15 | |||
| WO1999058502A1 | 1999-11-18 | |||
| WO1998027098A1 | 1998-06-25 |
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita