Title:
標的材料の蛍光検出用標識としてのアクリドン誘導体
Document Type and Number:
Japanese Patent JP2005500406
Kind Code:
A
Abstract:
Disclosed are methods for assay of an analyte employing acridone dyes having the structure: Z1 and Z2 represent atoms necessary to complete one ring, two fused ring, three fused ring aromatic or heteroaromatic systems, each ring having five or six atoms selected from carbon atoms and optionally no more than two atoms selected from oxygen, nitrogen and sulphur; R2, R3, R4 and R5 are selected from hydrogen, halogen, amide, hydroxyl, cyano, nitro, mono- or di-nitro-substituted benzyl, amino, mono- or di-C1-C4 alkyl-substituted amino, sulphydryl, carbonyl, carboxyl, C1-C6 alkoxy, acrylate, vinyl, styryl, aryl, heteroaryl, C1-C20 alkyl, aralkyl, sulphonate, sulphonic acid, quaternary ammonium, the groups -E-F and —(CH2—)nY; R1 is selected from hydrogen, mono- or di-nitro-substituted benzyl, C1-C20 alkyl, aralkyl, the groups -E-F and —(CH2—)nY; where E is a spacer group, F is a target bonding group; Y is selected from sulphonate, sulphate, phosphonate, phosphate, quaternary ammonium and carboxyl.
Inventors:
John Anthony Smith
Richard Martin West
Richard Martin West
Application Number:
JP2003502493A
Publication Date:
January 06, 2005
Filing Date:
May 30, 2002
Export Citation:
Assignee:
Amersham Biosciences UK Limited
International Classes:
G01N33/533; C07D219/06; C07D401/12; C09B15/00; C09K11/06; C12Q1/02; C12Q1/26; C12Q1/68; G01N21/78; G01N33/542; G01N33/58; (IPC1-7): C09B15/00; C07D219/06; C07D401/12; C09K11/06; C12Q1/02; C12Q1/26; C12Q1/68; G01N21/78; G01N33/533; G01N33/542
Domestic Patent References:
| JPH0666802A | 1994-03-11 | |||
| JPH05222033A | 1993-08-31 | |||
| JPH0881441A | 1996-03-26 | |||
| JPH05504363A | 1993-07-08 | |||
| JP2000507444A | 2000-06-20 | |||
| JPH09249650A | 1997-09-22 |
Foreign References:
| US3681360A | 1972-08-01 |
Other References:
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Attorney, Agent or Firm:
Aoyama Aoi
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima
Mitsutaka Iwasaki
Shoji Nakajima
Kazuaki Kojima