Title:
結晶型[R-(R*,R*)]-2-(4-フルオロフェニル)-β,δ-ジヒドロキシ-5-(1-メチルエチル)-3-フェニル-4-[(フェニルアミノ)カルボニル]-1H-ピロール-1-ヘプタン酸カルシウム塩(2:1)(アトロバスタチン)
Document Type and Number:
Japanese Patent JP2005501032
Kind Code:
A
Abstract:
Novel crystalline forms of [R-(R*,R*)]-2-(4-fluorophenyl)-², ;-dihydroxy-5-(1-methylethyl)-3-phenyl-4-[(phenylamino)carbonyl]-1H-pyrrole-1-heptanoic acid hemi calcium salt atorvastatin designated Form V, Form VI, Form VII, Form VIII, Form IX, Form X, Form XI, Form XII, Form XIII, Form XIV, Form XV, Form XVI, Form XVII, Form XVIII, and Form XIX are characterized by their X-ray powder diffraction, solid-state NMR, and/or Raman spectroscopy are described, as well as methods for the preparation and pharmaceutical composition of the same, which are useful as agents for treating hyperlipidemia, hypercholesterolemia, osteoporosis, and Alzheimer's disease.
Inventors:
Steven Robert Byrne
David Andrew Coates
Karen Sue Gushurst
Henry Grant Morrison the Second
Aeri Park
Petinka Ivanova Vrahova
Tseng Jane Lee
Joseph Francis Ksisianak
David Andrew Coates
Karen Sue Gushurst
Henry Grant Morrison the Second
Aeri Park
Petinka Ivanova Vrahova
Tseng Jane Lee
Joseph Francis Ksisianak
Application Number:
JP2003510638A
Publication Date:
January 13, 2005
Filing Date:
May 21, 2002
Export Citation:
Assignee:
WARNER-LAMBERT COMPANYLLC
International Classes:
A61K31/40; A61P3/06; A61P19/10; A61P25/28; C07D207/34; (IPC1-7): C07D207/34; A61K31/40; A61P3/06; A61P19/10; A61P25/28
Attorney, Agent or Firm:
Chika Takagi
Kosuke Nishimura
Junji Yuda
Shoji Miwa
Kosuke Nishimura
Junji Yuda
Shoji Miwa