Title:
C-JUN-N-末端キナーゼ(JNK)インヒビターとしてのアリールスルホンアミド誘導体
Document Type and Number:
Japanese Patent JP2005504031
Kind Code:
A
Abstract:
The present invention relates to sulfonamide derivatives of formula (I) notably for use as pharmaceutically active compounds, as well as to pharmaceutical formulations containing such sulfonamide derivatives. Said sulfonamide derivatives are useful in the treatment of neuronal disorders, autoimmune diseases, cancer and cardiovascular diseases. Furthermore, said sulfonamide derivatives are efficient modulators of the JNK pathway, they are in particular efficient and selective inhibitors of JNK2 and -3. The present invention is furthermore related to novel sulfonamide derivatives as well as to methods of their preparation. Formula (I) IAr1 is a substituted or unsubstituted aryl or heteroaryl group; X is O or S, preferably O; Ar2 a substituted or unsubstituted arylene or heteroarylene group; R1 and R2 are independently selected from the group consisting of hydrogen and a C1-C6-alkyl group.
Inventors:
Luke, Thomas
Gotlan, Jean-Pierre
Thomas, Russell Jay.
Viamonte, Marco
Gotlan, Jean-Pierre
Thomas, Russell Jay.
Viamonte, Marco
Application Number:
JP2003515523A
Publication Date:
February 10, 2005
Filing Date:
July 15, 2002
Export Citation:
Assignee:
Applied Research Systems ARS Holding Nam Rosé Fennaught Shap
International Classes:
A61K31/38; A61K31/381; A61K31/4025; A61K31/4535; A61P1/04; A61P1/16; A61P9/04; A61P9/10; A61P13/12; A61P19/00; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/00; C07D333/34; C07D409/12; (IPC1-7): C07D333/34; A61K31/381; A61K31/4025; A61K31/4535; A61P1/04; A61P1/16; A61P9/04; A61P9/10; A61P13/12; A61P19/00; A61P19/02; A61P25/00; A61P25/16; A61P25/28; A61P27/02; A61P29/00; A61P35/00; A61P37/00; C07D409/12
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama