Title:
非メバロン酸イソプレノイド経路の中間体及び酵素
Document Type and Number:
Japanese Patent JP2005505248
Kind Code:
A
Abstract:
The invention provides a protein in a form that is functional for the enzymatic conversion of 2C-methyl-D-erythritol 2,4-cyclodiphosphate to 1-hydroxy-2-methyl-2-butenyl 4-diphosphate notably in its (E)-form of the non-mevalonate biosynthetic pathway to isoprenoids. The invention also provides a protein in a form that is functional for the enzymatic conversion of 1-hydroxy-2-methyl-2-butenyl 4-diphosphate, notably in its (E)-form, to isopentenyl diphosphate and/or dimethylallyl diphosphate. Further, screening methods for inhibitors of these proteins are provided. Further, 1-hydroxy-2-methyl-2-butenyl 4-diphosphate is provided and chemical and enzymatic methods of its preparation.
Inventors:
Bach, Adelbert
Rodich, Felix
Adam and Petra
Amslinger, Sabine
Eisenreich, Wolfgang
Hecht, Stefan
Rodich, Felix
Adam and Petra
Amslinger, Sabine
Eisenreich, Wolfgang
Hecht, Stefan
Application Number:
JP2002581475A
Publication Date:
February 24, 2005
Filing Date:
April 10, 2002
Export Citation:
Assignee:
Bacher, Adelbad
Rodich, Felix
Rodich, Felix
International Classes:
G01N33/50; A61K31/663; A61P31/04; A61P37/02; A61P37/04; A61P43/00; C07C33/025; C07C33/035; C07C47/263; C07F9/09; C07F9/113; C07H19/10; C07K16/44; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N9/16; C12N9/88; C12N9/99; C12N15/09; C12N15/52; C12N15/55; C12P9/00; C12Q1/02; G01N33/15; G01N33/569; C07B61/00; (IPC1-7): C12N15/09; A61K31/663; A61P31/04; A61P37/02; A61P37/04; A61P43/00; C07C33/035; C07C47/263; C07F9/09; C07K16/44; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/02; C12N9/16; C12N9/88; C12N9/99; C12P9/00; C12Q1/02; G01N33/15; G01N33/50; G01N33/569
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda