Title:
GABAA受容体リガンドとしての、ヘテロアリール置換縮合二環式ヘテロアリール化合物
Document Type and Number:
Japanese Patent JP2005505518
Kind Code:
A
Abstract:
This invention relates to heteroaryl substituted fused bicyclic heteroaryl compounds, such as heteroaryl substituted imidazopyridines, imidazopyrazines, imidazopyridizines, imidazopyrimidines, and imidazothiazoles, which may be described by Formula I or Formula II: The invention is particularly related to such compounds that bind with high selectivity and high affinity to the benzodiazepine site of GABAA receptors. This invention also relates to pharmaceutical compositions comprising such compounds and to the use of such compounds in treatment of certain central nervous system (CNS) diseases. Processes for preparing compounds of Formula I and Formula II are disclosed. This invention also relates to the use of benzimidazoles, pyridylimidazoles and related bicyclic heteroaryl compounds of Formula I or Formula II in combination with one or more other CNS agents to potentiate the effects of the other CNS agents. Additionally this invention relates to the use such compounds as probes for the localization of GABAA receptors in tissue sections.
Inventors:
Hutchison, Alan
Maynard, George
Arbo, Pamela
Swie, ring horn
Yuan, Jun
Mitchell, Scott
Shin, Vinod
Gosh, Manuka
Li, Guy Inn
Liu, Nyan
Maynard, George
Arbo, Pamela
Swie, ring horn
Yuan, Jun
Mitchell, Scott
Shin, Vinod
Gosh, Manuka
Li, Guy Inn
Liu, Nyan
Application Number:
JP2003512241A
Publication Date:
February 24, 2005
Filing Date:
July 12, 2002
Export Citation:
Assignee:
Neurogen Corporation
International Classes:
A61K31/4355; A61K31/4439; A61K31/444; A61K31/4985; A61K31/5025; A61K31/506; A61K31/519; A61P25/00; A61P25/14; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D471/04; C07D487/04; C07D513/04; C12N15/09; C12Q1/02; G01N33/58; G01N33/60; G01N33/48; (IPC1-7): C07D471/04; A61K31/4355; A61K31/4439; A61K31/444; A61K31/4985; A61K31/5025; A61K31/506; A61K31/519; A61P25/14; A61P25/18; A61P25/20; A61P25/22; A61P25/24; A61P25/28; A61P43/00; C07D487/04; C07D513/04; C12N15/09; C12Q1/02; G01N33/48; G01N33/58; G01N33/60
Attorney, Agent or Firm:
Hideto Asamura
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda
Hajime Asamura
Naganuma Akio
Yukihiro Ikeda