Title:
予防または治療ワクチン接種および/或いはその他疾患の治療を目的とする、抗原提示細胞を標的とすることおよび/または活性化すること、並びに/またはカーゴ分子を運搬することへの生物学的活性HIV-1TAT、その断片または誘導体の使用
Document Type and Number:
Japanese Patent JP2005505520
Kind Code:
A
Abstract:
The present invention concerns a method for prophylactic and/or therapeutic vaccination and/or treatment and/or diagnosis of HIV/AIDS, other infectious diseases, inflammatory and angiogenic diseases and tumours which utilizes a biologically active HIV-1 Tat protein, fragments or derivates thereof, as a module with one or more of the following features: antigen, adjuvant and targeting-delivery system to specific antigen-presenting cells including dendritic cells, endothelial cells and macrophages. In particular, it is claimed that Tat can be used only in its biologically active form as an antigen, alone or combined with one or more other antigens, to prime or to boost protective immune responses against itself as well as other antigens and/or to deliver these antigen(s) as well as active compounds to dendritic cells, endothelial cells and macrophages, due to its capability of targeting these APC and of activating their maturation and functions and of increasing Th-1 type immune responses as an adjuvant. Therefore, due to these characteristics and to the distribution of these cells in the body (during physiological and pathological disorders), biologically active Tat, fragments or derivates thereof containing the RGD region, can be used for preventive, therapeutic and/or diagnostic purposes for HIV/AIDS, other infectious diseases, inflammatory and angiogenic diseases and tumors.
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Inventors:
Ensori Barbara
Application Number:
JP2003515259A
Publication Date:
February 24, 2005
Filing Date:
July 26, 2002
Export Citation:
Assignee:
Istituto Superiore Di Sanita
International Classes:
A61K31/711; A61K35/74; A61K35/76; A61K38/00; A61K39/00; A61K39/02; A61K39/04; A61K39/12; A61K39/39; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P13/02; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P31/00; A61P31/04; A61P31/06; A61P31/12; A61P31/16; A61P31/22; A61P33/00; A61P35/00; A61P37/02; A61P37/08; C07K14/16; C12N15/09; (IPC1-7): A61K38/00; A61K31/711; A61K35/74; A61K35/76; A61K39/00; A61K39/02; A61K39/04; A61K39/12; A61K39/39; A61K39/395; A61K45/00; A61K48/00; A61P1/00; A61P1/04; A61P3/10; A61P5/14; A61P9/00; A61P9/10; A61P11/00; A61P13/02; A61P15/00; A61P17/00; A61P17/06; A61P19/00; A61P19/02; A61P25/00; A61P27/02; A61P27/06; A61P29/00; A61P31/00; A61P31/04; A61P31/06; A61P31/12; A61P31/16; A61P31/22; A61P33/00; A61P35/00; A61P37/02; A61P37/08
Foreign References:
| WO1999027958A2 | 1999-06-10 |
Attorney, Agent or Firm:
Jyohei Yamashita