カリケマイシンの生合成およびそれに対する自己耐性をコードするミクロモノスポラ・エチノスポラ(Micromonosporaechinospora)遺伝子

Japanese Patent JP2005506050

A

An isolated gene cluster of Micromonospora echinospora which codes for calicheamicin biosynthesis. The biosynthetic gene cluster contains genes encoding proteins and enzymes used in the biosynthetic production of calicheamicin, including the aryltetrasaccharide and aglycone. The gene cluster also includes the gene coding for the protein conferring calicheamicin resistance. The invention also provides isolated genes of the biosynthetic cluster and their corresponding proteins. In addition, the invention relates to DNA hybridizing with the calicheamicin gene cluster and the isolated genes of that cluster. Expression vectors containing genes of the biosynthetic gene and their functional variants are also provided. The invention also relates to host cells conjugated with DNA isolated from the Micromonospora echinospora spp. calichensis genome.

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Thorne, John

JP2002578467A

March 03, 2005

November 28, 2001

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Sloan-Kettering Institute for Cancer Research

C12N15/09; A61K31/7048; A61P35/00; A61P35/02; C07H17/08; C07K14/195; C07K14/36; C12N1/21; C12N9/00; C12N15/52; C12P17/00; C12P19/56; C12P19/62; C12P19/64; (IPC1-7): C12N15/09; A61K31/7048; A61P35/00; A61P35/02; C07H17/08; C07K14/195; C12N1/21

Atsushi Aoki
Takashi Ishida
Tetsuji Koga
Kazuhiro Nakamura
Masaya Nishiyama

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