新規ピリジルシアノグアニジン化合物

Japanese Patent JP2005508859

A

Compounds according to formula I wherein R1 represents hydrogen, halogen or one or more straight or branched, saturated or unsaturated C1-6 hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, carboxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, amino, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy or phosphono; X represents a straight or branched, saturated or unsaturated C1-12 hydrocarbon diradical, optionaly substituted with halogen, hydroxy, cyano, nitro, carboxy, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, amino, aminoalkyl, aminocarbonyl, alkylcarbonylamino, sulfo, aminosulfonyl, alkylsulfonylamino, hydroxysulfonyloxy, dihydroxyphosphinoyloxy or phosphono; Y represents a bond, 0, C(O), S, S(O), S(0)2, C(O)O, NH, C(O)NH, OC(O) or NHC(O); Z represents an aromatic or non-aromatic heterocyclic radical with 5-12 ring atoms, optionally substituted with halogen, hydroxy, cyano, nitro, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl, aminoalkyl or straight or branched, saturated or unsaturated C1-4 hydrocarbon radical, optionally substituted with halogen, hydroxy, cyano, nitro, alkoxy, alkoxycarbonyl, alkylcarbonyl, formyl or aminoalkyl; provided that R1 is not attached to the nitrogen-atom in the pyridyl ring; and pharmaceutically acceptable salts, solvates, hydrates, N-oxides and prodrugs thereof are disclosed. The compounds are useful in therapy.

JP2002506851	INDUSTRIAL APPLICABILITY The title of the invention: carboxylic acids and acyl sulfonamides, compositions containing such compounds, and therapeutic methods.
WO/2009/080223	CYCLIC PYRIDYL-N-(1,3,4)-THIADIAZOL-2-YL-BENZENE SULFONAMIDES, PROCESSES FOR THEIR PREPARATION AND THEIR USE AS PHARMACEUTICALS
JP7383635	Substituted benzofurans, benzopyrroles, benzothiophenes, and structurally related complement inhibitors

Frederik Björk Ring

JP2002591486A

April 07, 2005

May 24, 2002

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LEO Pharma A/S

A61K31/4439; A61K31/444; A61K31/4709; A61K31/506; A61K45/00; A61K45/06; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P11/00; A61P13/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P29/00; A61P35/00; A61P35/02; C07D213/89; C07D213/75; C07D401/12; (IPC1-7): C07D213/75; A61K31/4439; A61K31/444; A61K31/4709; A61K31/506; A61K45/00; A61P1/00; A61P1/16; A61P1/18; A61P7/00; A61P11/00; A61P13/00; A61P13/08; A61P13/12; A61P15/00; A61P17/00; A61P19/00; A61P29/00; A61P35/00; A61P35/02; C07D401/12

Aoyama Aoi
Yasuo Shibata

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