Title:
ポリアミン経路の調節による神経変性障害の治療
Document Type and Number:
Japanese Patent JP2005510524
Kind Code:
A
Abstract:
The present invention provides methods and compositions for modulating polyamine pathway activity as a means for ameliorating neurodegenarative disorders. In particular, for ameliorating the symptoms or onset of amyotrophic lateral sclerosis (ALS) by modulating the gene and protein products involved the polyamine pathway, such as by inhibiting the enzyme, ornithine decarboxylase (ODC), involved in the synthesis of the polyamine, putrescine. Compositions and methods are disclosed for inhibiting the polyamine pathway producing lower polyamine levels resulting in a beneficial effect on ALS. This can be accomplished by using modulating agents such as analogs, or polyamine analogs, and antiproliferative drugs. In particular, the ODC inhibitor difuoromethylornithine (DFMO) is disclosed as a useful pharmacological agent in the modulation and treatment of ALS. Screening assays for pharmacological agents that are capable of decreasing polyamine levels and/or reducing cell proliferation are also disclosed.
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Inventors:
Tenor, Lameille M
Scott, scene
Scott, scene
Application Number:
JP2003545297A
Publication Date:
April 21, 2005
Filing Date:
November 01, 2002
Export Citation:
Assignee:
Ars Therapy Development Foundation Incorporated
International Classes:
A61K45/00; A61K31/00; A61K31/13; A61K31/132; A61K31/135; A61K31/17; A61K31/198; A61P21/00; A61P25/00; C12Q1/02; G01N33/15; G01N33/48; G01N33/50; G01N33/569; G01N33/68; (IPC1-7): A61K45/00; A61K31/132; A61K31/17; A61P21/00; A61P25/00
Attorney, Agent or Firm:
Heikichi Odashima
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