Title:
免疫反応の変化を生じるプロテアーゼ、ならびにその製造および利用方法
Document Type and Number:
Japanese Patent JP2005514026
Kind Code:
A
Abstract:
The present invention provides novel protein variants that exhibit reduced immunogenic responses, as compared to the parental proteins. The present invention further provides DNA molecules that encode novel variants, host cells comprising DNA encoding novel variants, as well as methods for making proteins less allergenic. In addition, the present invention provides various compositions that comprise these proteins that are less immunogenic than the wild-type proteins.
Inventors:
Esther, David A.
Harding, Fiona A
Pau Rose, Ale Curran Jay
Harding, Fiona A
Pau Rose, Ale Curran Jay
Application Number:
JP2003557603A
Publication Date:
May 19, 2005
Filing Date:
December 20, 2002
Export Citation:
Assignee:
Genenco International Inc.
International Classes:
A61K8/00; A61K8/02; A61K8/06; A61K8/30; A61K8/33; A61K8/34; A61K8/36; A61K8/365; A61K8/55; A61K8/58; A61K8/64; C12N15/09; A61K8/66; A61K8/67; A61K8/72; A61K8/86; A61K38/46; A61P17/16; A61Q19/00; A61Q19/10; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/54; C12N9/56; C12R1/07; (IPC1-7): C12N15/09; A61K7/00; A61K7/50; A61K38/46; A61P17/16; C12N1/15; C12N1/19; C12N1/21; C12N5/10; C12N9/56
Foreign References:
| WO2001059130A2 | 2001-08-16 | |||
| WO1999053038A2 | 1999-10-21 | |||
| WO2001007575A2 | 2001-02-01 |
Attorney, Agent or Firm:
Yuzo Yamazaki
Naoto Sugiyama
Shirogane Expo
Takako Hoshi
Toshiaki Akamatsu
Kazuki Shigemori
Naoto Sugiyama
Shirogane Expo
Takako Hoshi
Toshiaki Akamatsu
Kazuki Shigemori