Title:
IMPDH酵素のアクリドンインヒビター
Document Type and Number:
Japanese Patent JP2005514434
Kind Code:
A
Abstract:
Compounds having the formula (I), wherein R3 is selected from H, OH and NH2; R30 is selected from -O and -S; W is -C(-O)-, -S(-O)-, or -S(O)2-; or W may be -CH2- if X is -C(-O)-; X is selected from -CH2-, -N(R4)-, and -O-, except that when W is -CH2-, X is -C(-O)-; Y is a bond or -C(R40)(R45)-; Q is a linker; Z is optionally substituted alkyl, alkenyl, alkynyl, cycloalkyl, aryl, heteroaryl, or heterocyclyl; and X1, X2, X3, X4, X5, X6, X7, X8, X9, X10 and X11 are selected such a tricyclic heteroaryl ring system is formed as further defined in the specification.
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Inventors:
Edwin Jay Ivanowitz
Scott H. Watterson
Chen Pin
T. G. Murari Dar
Gu Henry H
Jao Yufen
Scott H. Watterson
Chen Pin
T. G. Murari Dar
Gu Henry H
Jao Yufen
Application Number:
JP2003559434A
Publication Date:
May 19, 2005
Filing Date:
December 20, 2002
Export Citation:
Assignee:
BRISTOL-MYERS SQUIBB COMPANY
International Classes:
A61K31/437; A61K31/4375; A61K31/473; A61K31/496; A61K31/4985; A61K31/506; A61K31/5377; A61K31/538; A61K31/5383; A61K31/5386; A61K31/541; A61K31/551; A61K45/00; A61P1/04; A61P1/18; A61P3/10; A61P5/14; A61P5/18; A61P7/06; A61P9/00; A61P9/10; A61P11/00; A61P11/06; A61P13/12; A61P17/00; A61P17/06; A61P17/14; A61P19/02; A61P21/04; A61P29/00; A61P31/00; A61P31/10; C07D219/04; A61P31/12; A61P35/00; A61P37/06; A61P37/08; A61P43/00; C07D219/06; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D471/04; C07D487/04; C07D491/08; C07D498/04; (IPC1-7): C07D219/04; A61K31/473; A61K31/496; A61K31/4985; A61K31/506; A61K31/5377; A61K31/538; A61K31/5383; A61K31/5386; A61K31/541; A61K31/551; A61K45/00; A61P9/00; A61P17/06; A61P29/00; A61P31/10; A61P31/12; A61P35/00; A61P37/06; A61P43/00; C07D401/12; C07D401/14; C07D405/12; C07D405/14; C07D413/12; C07D413/14; C07D417/12; C07D487/04; C07D491/08; C07D498/04
Domestic Patent References:
| JPH10158261A | 1998-06-16 | |||
| JPS63305173A | 1988-12-13 |
Foreign References:
| WO1998042332A1 | 1998-10-01 |
Attorney, Agent or Firm:
Kyousei Tamura
Toshio Ueda
Nagatoshi Shinagawa
Toshio Ueda
Nagatoshi Shinagawa