Title:
白板症を処置するためのβカロチン澄明ミセル化製剤
Document Type and Number:
Japanese Patent JP2005516991
Kind Code:
A
Abstract:
A clear aqueous formulation for topical application in the oral cavity of humans to treat leukoplakia contains water, beta-carotene, a water miscible polyol, an unsaturated fatty acid ester, and a surfactant, preferably polyethoxylated castor oil or POE(20) sorbitan monooleate. The formulation preferably also contains a pharmaceutically acceptable anti-oxidant, preferably d-alpha-tocopherol (vitamin E), and is in the form of an oral rinse or as a gel well suited for spreading on gums or other parts of the oral cavity. The formulation is applied in a gel form on a substantially regular daily basis to areas in the oral cavity where leukoplakia lesions are present. Persistent application of the gel results in substantial diminution or total elimination of the leukoplakia lesions.
Inventors:
Wenge Li
Edward arosio
David A. Lutro Jr.
Buritini Face (Bim) Hoax-Ala
Edward arosio
David A. Lutro Jr.
Buritini Face (Bim) Hoax-Ala
Application Number:
JP2003565450A
Publication Date:
June 09, 2005
Filing Date:
January 23, 2003
Export Citation:
Assignee:
Micelle Products, Inc.
International Classes:
A61K9/06; A61K8/00; A61K8/34; A61K8/36; A61K8/368; A61K8/37; A61K8/40; A61K8/41; A61K9/00; A61K9/08; A61K9/107; A61K31/015; A61K31/07; A61K31/355; A61K47/10; A61K47/14; A61K47/22; A61K47/34; A61P1/02; A61Q11/00; (IPC1-7): A61K31/07; A61K7/16; A61K9/06; A61K9/08; A61K47/10; A61K47/14; A61K47/22; A61K47/34; A61P1/02
Domestic Patent References:
| JPH06321771A | 1994-11-22 | |||
| JPS60233010A | 1985-11-19 | |||
| JP2001072561A | 2001-03-21 | |||
| JP2001213768A | 2001-08-07 | |||
| JPH09511508A | 1997-11-18 | |||
| JP2001514207A | 2001-09-11 |
Attorney, Agent or Firm:
Kyousei Tamura
Hiromitsu Takayama
Minato Saito
Hiromitsu Takayama
Minato Saito