Title:
インシュリン及びIGF-1レセプターのアゴニスト及びアンタゴニスト
Document Type and Number:
Japanese Patent JP2005517741
Kind Code:
A
Abstract:
Peptide sequences capable of binding to insulin and/or insulin-like growth factor receptors with either agonist or antagonist activity and identified from various peptide libraries are disclosed. This invention also identifies at least two different binding sites, which are present on insulin and insulin-like growth factor receptors, and which selectively bind the peptides of this invention. As agonists, certain of the peptides of this invention may be useful for development as therapeutics to supplement or replace endogenous peptide hormones. The antagonists may also be developed as therapeutics.
Inventors:
Pilutura, Renuka
Blythe, Lenny
Bloom, Arthur, Jay.
Scheffer, Lauge
Brandt, Jacob
Goldstein, Neil, Eye.
Jane Spetsler
Ostergirl, Soren
Blythe, Lenny
Bloom, Arthur, Jay.
Scheffer, Lauge
Brandt, Jacob
Goldstein, Neil, Eye.
Jane Spetsler
Ostergirl, Soren
Application Number:
JP2003569654A
Publication Date:
June 16, 2005
Filing Date:
September 24, 2002
Export Citation:
Assignee:
Novo Nordeisk A/S
DG Eye Biotechnology
DG Eye Biotechnology
International Classes:
G01N33/50; A61K38/00; A61K48/00; A61P3/10; A61P43/00; C07K7/06; C07K7/08; C07K14/00; C07K14/62; C07K14/65; C12N5/07; C12N5/077; C12N5/09; C12N15/09; G01N33/15; (IPC1-7): C07K7/06; A61K38/00; A61K48/00; A61P3/10; A61P43/00; C07K7/08; G01N33/15; G01N33/50
Foreign References:
| WO1998032017A2 | 1998-07-23 |
Attorney, Agent or Firm:
Sonoda Yoshitaka
Kobayashi Yoshinori
Kobayashi Yoshinori