Title:
肝搬送のため、修飾オリゴヌクレオチドを用いる方法
Document Type and Number:
Japanese Patent JP2005518452
Kind Code:
A
Abstract:
A method of modulating the expression of a nucleic acid in the hepatic system of a mammal is disclosed. In addition, a method of preferentially targeting an oligonucleotide to liver cells in a mammal is disclosed. Also, a method of treating an animal having a hepatic disease or disorder associated with a protein encoded by a gene is disclosed. A composition containing an oligonucleotide is disclosed.
Inventors:
Cook, Philip Dunn
Manoharan, Musa
Bennett, Frank Sea
Manoharan, Musa
Bennett, Frank Sea
Application Number:
JP2003571399A
Publication Date:
June 23, 2005
Filing Date:
February 21, 2003
Export Citation:
Assignee:
Isis PharmaceuticalsInc
International Classes:
A61K31/7125; A61K47/48; A61K48/00; A61P1/16; C12N15/113; C12N15/09; C12N15/87; (IPC1-7): A61K48/00; A61K31/7125; A61K47/48; A61P1/16
Attorney, Agent or Firm:
Kazuo Shamoto
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa
Tadashi Masui
Yasushi Kobayashi
Akio Chiba
Hiroyuki Tomita
Norihiro Fukasawa