Title:
2-アミノキノリン化合物
Document Type and Number:
Japanese Patent JP2005519876
Kind Code:
A
Abstract:
The present invention is concerned with compounds of the general Formula I: and pharmaceutically acceptable salts thereof, which are useful as melanin concentrating hormone receptor antagonists, particularly MCH-1R antagonists. As such, compounds of the present invention are useful for the treatment or prevention of obesity or eating disorders associated with excessive food intake and complications thereof, osteoarthritis, certain cancers, AIDS wasting, cachexia, frailty (particularly in elderly), mental disorders stress, cognitive disorders, sexual function, reproductive function, kidney function, locomotor disorders, attention deficit disorder (ADD), substance abuse disorders and dyskinesias, Huntington's disease, epilepsy, memory function, and spinal muscular atrophy. Compounds of formula I may therefore be used in the treatment of these conditions, and in the manufacture of a medicament useful in treating these conditions. Pharmaceutical formulations comprising one of the compounds of formula (I) as an active ingredient are disclosed, as are processes for preparing these compounds.
Inventors:
Debita, Robert Jay
Chillan, Ruhua
Danny
Hoang, Millet
Ji Yang, Jin Long
Lin, Peter
Sailer, Andreas Davryu
Young, Jyonathan Earl
Chillan, Ruhua
Danny
Hoang, Millet
Ji Yang, Jin Long
Lin, Peter
Sailer, Andreas Davryu
Young, Jyonathan Earl
Application Number:
JP2003546818A
Publication Date:
July 07, 2005
Filing Date:
November 22, 2002
Export Citation:
Assignee:
MERCK & COMPANY INCOPORATED
International Classes:
C07D215/38; A61K31/403; A61K31/407; A61K31/439; A61K31/47; A61K31/4709; A61K31/496; A61K31/4995; A61K31/5377; A61K31/54; A61K31/55; A61P1/14; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P15/00; A61P19/02; A61P21/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P35/00; A61P43/00; C07D215/227; C07D401/04; C07D401/12; C07D401/14; C07D405/04; C07D405/14; C07D413/14; C07D417/04; C07D417/12; C07D417/14; C07D453/00; C07D471/08; C07D487/08; C07D487/10; C07D491/04; C07D491/08; C07D495/10; C07D215/22; (IPC1-7): C07D215/38; A61K31/403; A61K31/407; A61K31/439; A61K31/47; A61K31/4709; A61K31/496; A61K31/4995; A61K31/5377; A61K31/54; A61K31/55; A61P1/14; A61P1/16; A61P3/00; A61P3/04; A61P3/06; A61P3/10; A61P7/00; A61P7/10; A61P9/00; A61P9/10; A61P9/12; A61P13/12; A61P15/00; A61P19/02; A61P21/00; A61P25/02; A61P25/08; A61P25/14; A61P25/16; A61P25/18; A61P25/22; A61P25/24; A61P25/28; A61P25/30; A61P35/00; A61P43/00; C07D401/04; C07D401/12; C07D401/14; C07D405/04; C07D413/14; C07D417/12; C07D453/00; C07D471/08; C07D487/08; C07D487/10; C07D491/08; C07D495/10
Domestic Patent References:
| JP2002003370A | 2002-01-09 | |||
| JP2004536066A | 2004-12-02 | |||
| JPH10316664A | 1998-12-02 | |||
| JPS5933264A | 1984-02-23 | |||
| JPH11335355A | 1999-12-07 | |||
| JP2001064529A | 2001-03-13 |
Foreign References:
| WO2001010842A2 | 2001-02-15 | |||
| WO2000064877A1 | 2000-11-02 | |||
| WO2000076984A2 | 2000-12-21 | |||
| US3743732A | 1973-07-03 | |||
| WO1994017066A1 | 1994-08-04 | |||
| WO1999048492A1 | 1999-09-30 | |||
| WO1996006084A1 | 1996-02-29 |
Attorney, Agent or Firm:
Yoshio Kawaguchi
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura
Akio Ichiiri
Makoto Ono
Katsuma Osaki
Mitsuaki Tsubokura