Title:
抗癌組み合わせおよびその使用方法
Document Type and Number:
Japanese Patent JP2005519900
Kind Code:
A
Abstract:
The present invention relates to the surprising discovery that the combination of several agents, each well known for its established role in treating cancer, inflammation, hemostasis, bone resorption or serving as a solubilizing vehicle, results in a synergistic anti-cancer composition. Furthermore, the combination of at least three agents allows the cytotoxic agent, such as cyclophosphamide, to be used at a lower dosage than when administered alone. One predicted consequence of this treatment, therefore, is a highly desirable reduction in toxic side effects due to the cytotoxic agent.
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Inventors:
Ben-Sason Shmuel A.
Ziral Nikof Liria
Beinstein Vladimir
Ziral Nikof Liria
Beinstein Vladimir
Application Number:
JP2003561512A
Publication Date:
July 07, 2005
Filing Date:
December 31, 2002
Export Citation:
Assignee:
Issam Research Development Company of the Hebrew University of Jerusalem
Children's Medical Center Corporation
Children's Medical Center Corporation
International Classes:
A61K31/12; A61K31/122; A61K31/195; A61K31/196; A61K31/337; A61K31/405; A61K31/4745; A61K31/522; A61K31/525; A61K31/573; A61K31/65; A61K31/663; A61K31/675; A61K31/704; A61K45/06; A61P3/06; A61P9/00; A61P35/00; A61P43/00; (IPC1-7): A61K45/06; A61K31/122; A61K31/196; A61K31/405; A61K31/573; A61K31/65; A61K31/663; A61K31/675; A61P3/06; A61P9/00; A61P35/00; A61P43/00
Domestic Patent References:
| JPH08502300A | 1996-03-12 | |||
| JPH11514673A | 1999-12-14 | |||
| JP2001524510A | 2001-12-04 | |||
| JPS5634625A | 1981-04-06 | |||
| JPH03271261A | 1991-12-03 | |||
| JPH10114680A | 1998-05-06 | |||
| JP2001512830A | 2001-08-28 |
Foreign References:
| WO2001064251A2 | 2001-09-07 | |||
| WO2000040275A2 | 2000-07-13 | |||
| WO2000066093A2 | 2000-11-09 | |||
| WO2000047228A1 | 2000-08-17 | |||
| WO1999062983A1 | 1999-12-09 |
Other References:
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JPN6009006709, ＤＥ，Ｌ．Ｏ． ｅｔ ａｌ, "Ｅｆｆｅｃｔｓ ｏｆ ｓｏｄｉｕｍ ａｓｃｏｒｂａｔｅ （ｖｉｔａｍｉｎ Ｃ） ａｎｄ ２−ｍｅｔｈｙｌ−１，４−ｎａｐｈｔｈｏｑｕｉｎｏｎｅ （ｖｉｔａｍｉｎ Ｋ３） ｔｒｅａｔｍｅｎｔ ｏｎ ｈｕ", Ａｎｔｉｃａｎｃｅｒ Ｒｅｓ, 1993, Ｖｏｌ．１３， Ｎｏ．１, ｐ．１０３−６
JPN6009006711, ＬＩＡＯ， Ｗ．Ｃ． ｅｔ ａｌ, "Ｓｙｎｅｒｇｉｓｔｉｃ ｅｆｆｅｃｔｓ ｏｆ ａｎｔｉｔｕｍｏｒ ｄｒｕｇ ｖｉｔａｍｉｎ Ｋ３ ａｎｄ ｏｔｈｅｒ ａｎｔｉｃａｎｃｅｒ ｄｒｕｇｓ ｏｎ ｈｅｐａｔｏｃｅｌｌｕｌａｒ， ｃｅｒｖｉ", Ｐｒｏｃ Ａｎｎｕ Ｍｅｅｔ Ａｍ Ａｓｓｏｃ Ｃａｎｃｅｒ Ｒｅｓ, 1996, Ｖｏｌ．３７, ｐ．２９２
JPN6009045347, ＴＥＩＣＨＥＲ，Ｂ．Ａ． ｅｔ ａｌ, "Ｃｙｃｌｏｏｘｙｇｅｎａｓｅ ａｎｄ ｌｉｐｏｘｙｇｅｎａｓｅ ｉｎｈｉｂｉｔｏｒｓ ａｓ ｍｏｄｕｌａｔｏｒｓ ｏｆ ｃａｎｃｅｒ ｔｈｅｒａｐｉｅｓ", Ｃａｎｃｅｒ Ｃｈｅｍｏｔｈｅｒ Ｐｈａｒｍａｃｏｌ, 1994, Ｖｏｌ．３３， Ｎｏ．６, ｐ．５１５−２２
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi