Title:
慢性的移植片拒絶反応の治療と予防のためのTGF-β拮抗薬の使用
Document Type and Number:
Japanese Patent JP2005519902
Kind Code:
A
Abstract:
Effective use of a TGF-beta antagonist to treat or to prevent loss of transplant function is described herein. Use of a TGF-beta antagonist is demonstrated to effectively prevent loss of organ function in a host due to chronic rejection in which TGF-beta-mediated fibroproliferation is a characteristic. Expression in situ of a TGF-beta antagonist in the form of a recombinant receptor, i.e., TGF-beta type III receptor (TGFBIIIR) showed prevention of bronchiolitis obliterans in comparison to untreated controls in a rat lung transplant model. This provides an effective method for preventing or inhibiting chronic rejection of transplant organs such as lung, kidney, liver and heart in vertebrate hosts including human hosts.
Inventors:
Kesha Buzzi shuff
St. George Shdis A.
Liu Min Gao
St. George Shdis A.
Liu Min Gao
Application Number:
JP2003561533A
Publication Date:
July 07, 2005
Filing Date:
January 21, 2003
Export Citation:
Assignee:
GENZYME CORPORATION
International Classes:
A61K45/00; A61K31/00; A61K31/194; A61K31/7004; A61K38/17; A61K38/18; A61K38/22; A61K38/30; A61K38/31; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P37/06; C07K14/495; C07K14/71; A61K38/00; A61K48/00; (IPC1-7): A61K45/00; A61P1/16; A61P9/00; A61P11/00; A61P13/12; A61P37/06
Other References:
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Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi