Title:
オメプラゾール及びエソメプラゾールのアルキルアンモニウム塩
Document Type and Number:
Japanese Patent JP2005521693
Kind Code:
A
Abstract:
The present invention relates to new salts of omeprazole and esomeprazole respectively, i.e. salts of 5-methoxy-2-[[(4-methoxy-3,5-dimethyl-2-pyridinyl)-methyl]sulfinyl]-1H-benzirnidazole and the (S)-enantiomer thereof. More specifically, the present invention relates to alkylammonium salts of the compounds, formed by a reaction of omeprazole and esomeprazole respectively and an alkylamine with formula NR1R2R3, wherein R1 is a linear, branched, or cyclic C1-C12-alkyl group, and R2 and R3 are hydrogen. The present invention also relates to a process for preparing crystalline salts, a pharmaceutical preparation, and a method for treatment of gastric related disorders by administering the compound of the invention.
Inventors:
Michael Dahlström
Application Number:
JP2003572982A
Publication Date:
July 21, 2005
Filing Date:
March 04, 2003
Export Citation:
Assignee:
ASTRAZENECA AKTIEBOLAG
International Classes:
A61K31/4439; A61P1/04; B01D9/02; C07D401/12; (IPC1-7): C07D401/12; A61K31/4439; A61P1/04; B01D9/02
Domestic Patent References:
| JP2000509067A | 2000-07-18 | |||
| JPS59167587A | 1984-09-21 | |||
| JPH07509499A | 1995-10-19 | |||
| JPS62258320A | 1987-11-10 | |||
| JPH05294831A | 1993-11-09 | |||
| JP2002501529A | 2002-01-15 | |||
| JPH09502739A | 1997-03-18 | |||
| JPH10504290A | 1998-04-28 | |||
| JPS54141783A | 1979-11-05 | |||
| JPH07508509A | 1995-09-21 |
Foreign References:
| US6048981A | 2000-04-11 |
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa