Title:
キラルN-アリールピペラジンの合成方法
Document Type and Number:
Japanese Patent JP2005526775
Kind Code:
A
Abstract:
A process for formation of N-aryl piperazines with chiral N'-1-[benzoyl(2-pyridyl)amino]-2-propane side-chains having the structure shown in formula below, and for making intermediate compounds therefor.In this process, chirality is introduced at the piperazine ring formation step and 2-aminopyridyl substitution is incorporated via displacement. The resulting N,N' disubstituted piperazines act on the central nervous system at 5HT receptors.
Inventors:
Greg Bryan Fagelson
Joseph Zeldis
Aibo Djakovsky
Joseph Zeldis
Aibo Djakovsky
Application Number:
JP2003576423A
Publication Date:
September 08, 2005
Filing Date:
March 10, 2003
Export Citation:
Assignee:
Wyeth
International Classes:
C07D319/18; C07D405/12; (IPC1-7): C07D405/12
Attorney, Agent or Firm:
Mitsuo Tanaka
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita
Michiko Matsutani
Tadayuki Motoyama
Kenji Tomita