Title:
心臓伝導障害の矯正のための方法および組成物
Document Type and Number:
Japanese Patent JP2005527482
Kind Code:
A
Abstract:
The invention provides methods for establishing electrical coupling between cardiomyocytes and recombinant cells which have been genetically engineered to express a connexin protein such as connexin 43 (Cx43) protein. The invention is based on the discovery that genetic modification of skeletal muscle cells to express a recombinant connexin, enables the genetically modified cells to establish electrocommunication with cardiac cells via gap junctions. The recombinant connexin-expressing cells can be used for repair of cardiac tissue and for treatment of cardiac disease by transplantation into cardiac tissue.
Inventors:
Lee Randall Jay.
Application Number:
JP2003541442A
Publication Date:
September 15, 2005
Filing Date:
November 07, 2002
Export Citation:
Assignee:
The Legends of the University of California San Diego
International Classes:
A61K35/28; A61K35/34; A61K48/00; A61P9/00; A61P9/10; A61L27/00; A61P43/00; C12N5/02; C12N5/077; C12N15/00; C12P21/06; A61K35/12; C12N; (IPC1-7): A61K35/28; A61K35/34; A61L27/00; A61P9/00; A61P9/10; A61P43/00
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi