Title:
結晶性パレコキシブナトリウム
Document Type and Number:
Japanese Patent JP2005529084
Kind Code:
A
Abstract:
Parecoxib sodium is provided in a crystalline form that is substantially anhydrous and substantially nonsolvated. Various such anhydrous, nonsolvated crystal forms have been identified, including Forms A, B and E as described herein. Also provided is a parecoxib sodium drug substance wherein at least about 90% of the parecoxib sodium is in one or more anhydrous, nonsolvated crystal forms. Such a drug substance is a storage-stable intermediate that can be further processed, for example by dissolution or slurrying in an aqueous medium together with one or more parenterally acceptable excipients, followed by lyophilization of the resulting solution or slurry to provide a reconstitutable injectable composition suitable for therapeutic use.
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Inventors:
Ahmad Wai Shake
Thomas Earl Chart
Leonard J. Ferro
Gerald Dee Dunzer
Thomas Earl Chart
Leonard J. Ferro
Gerald Dee Dunzer
Application Number:
JP2003576414A
Publication Date:
September 29, 2005
Filing Date:
March 12, 2003
Export Citation:
Assignee:
Pharmacia Corporation
International Classes:
A61K9/08; A61K9/16; A61K9/19; A61K31/42; A61P29/00; A61P43/00; C07D231/12; C07D261/08; C07D457/06; (IPC1-7): C07D261/08; A61K9/08; A61K9/16; A61K9/19; A61K31/42; A61P29/00; A61P43/00
Attorney, Agent or Firm:
Chika Takagi
Junji Yuda
Shoji Miwa
Junji Yuda
Shoji Miwa