Title:
化学工程
Document Type and Number:
Japanese Patent JP2005529148
Kind Code:
A
Abstract:
3-Isochromanone is prepared by partially chlorinating o-tolylacetic acid with sulphuryl chloride or chlorine gas in an inert organic solvent in the presence of a free radical initiator. The 2-chloromethylphenylacetic acid first obtained is converted to 3-isochromanone by treatment with a base and separated from unreacted o-tolylacetic acid, which is in the form of a salt, by a phase separation technique. The separated o-tolylacetic acid salt is converted to o-tolylacetic acid by controlled acidification and the o-tolylacetic acid is extracted for re-use. The invention reduces the formation of unwanted, over-chlorinated by-products and leads to a more efficient process.
Inventors:
Jones, Raymond Vincent Hepburn
Alan John Whitton
Benny, Colin John
Rich, david john
Bouillon, Pascal
Alan John Whitton
Benny, Colin John
Rich, david john
Bouillon, Pascal
Application Number:
JP2004503458A
Publication Date:
September 29, 2005
Filing Date:
April 08, 2003
Export Citation:
Assignee:
Syngenta Limited
Syngenta Partitions Akchen Gesell Shaft
Syngenta Partitions Akchen Gesell Shaft
International Classes:
C07B61/00; C07D311/76; (IPC1-7): C07D311/76
Domestic Patent References:
| JP2000512983A | 2000-10-03 | |||
| JPH11302220A | 1999-11-02 | |||
| JP2001002672A | 2001-01-09 | |||
| JPH09278772A | 1997-10-28 | |||
| JPH09278771A | 1997-10-28 |
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Yoichi Watanabe
Masaya Nishiyama