Title:
メチル化免疫刺激性オリゴヌクレオチド及びその使用方法
Document Type and Number:
Japanese Patent JP2005532315
Kind Code:
A
Abstract:
The invention discloses that methylated nucleic acids, particularly methylated oligonucleotides, and more particularly methylated oligonucleotides bearing a methylated cytosine of a CpG dinucleotide motif can be made immunostimulatory in vivo, by encapsulation of the nucleic acid in a lipid particle. It is further disclosed that encapsulated methylated nucleic acids that are ordinarily not immunostimulatory in vivo are as effective or even more effective than their encapsulated unmethylated counterparts. Also disclosed are methods for activating and/or expanding dendritic cell populations in response to antigenic stimulation using the compositions and methods disclosed herein.
Inventors:
Tom, Ink.
Semple, Sean
Climac, sandra
Chik, Gania
Semple, Sean
Climac, sandra
Chik, Gania
Application Number:
JP2004503046A
Publication Date:
October 27, 2005
Filing Date:
May 12, 2003
Export Citation:
Assignee:
INEX Pharmaceuticals Corporation
International Classes:
A61K48/00; A61K39/00; A61K39/39; A61K47/18; A61P31/00; A61P31/04; A61P35/00; A61P37/00; A61P37/02; A61P37/04; C12N15/09; C12N15/117; (IPC1-7): A61K39/39; A61K47/18; A61P31/00; A61P35/00
Attorney, Agent or Firm:
Atsushi Aoki
Takashi Ishida
Fukumoto product
Tetsuji Koga
Rieko Koshisakabe
Masaya Nishiyama
Takashi Ishida
Fukumoto product
Tetsuji Koga
Rieko Koshisakabe
Masaya Nishiyama