Title:
特異的かつ選択的な電気シグナル及び電磁シグナルを用いたタイプIIコラーゲン遺伝子発現の制御方法
Document Type and Number:
Japanese Patent JP2006501853
Kind Code:
A
Abstract:
Methods and devices for the regulation of type II collagen gene expression in cartilage cells via the application of specific and selective fields generated by specific and selective electric and electromagnetic signals in the treatment of diseased or injured articular cartilage. By gene expression is meant the up regulation or down regulation of the process whereby specific portions (genes) of the human genome (DNA) are transcribed into mRNA and subsequently translated into protein. Methods and devices are provided for the targeted treatment of injured or diseased cartilage tissue that include generating specific and selective electric and electromagnetic signals that generate specific and selective fields optimized for type II collagen gene expression and exposing cartilage tissue to the specific and selective fields generated by specific and selective signals so as to regulate type II collagen gene expression in such cartilage tissue. The resulting methods and devices are useful for the targeted treatment of osteoarthritis, rheumatoid arthritis, cartilage injury, and cartilage defects.
Inventors:
Brighton, curl, tea.
Application Number:
JP2004543486A
Publication Date:
January 19, 2006
Filing Date:
October 07, 2003
Export Citation:
Assignee:
The Trustees of the University of Pennsylvania
International Classes:
C12N15/09; A61N1/32; A61N1/40; A61N2/04; C12N5/07; C12N5/077; C12N13/00
Foreign References:
| WO2001062336A1 | 2001-08-30 |
Attorney, Agent or Firm:
Taro Yaguchi
Junichi Omori
Yasuaki Yamaguchi
Junichi Omori
Yasuaki Yamaguchi