Title:
HIVワクチン処方物
Document Type and Number:
Japanese Patent JP2006502228
Kind Code:
A
Abstract:
Provided herein are HIV vaccines comprising HIV polypeptide-encoding DNA adsorbed to PLG and/or HIV proteins. Also provided are methods of using these vaccines to generate immune responses in a subject.
Inventors:
Donnelly, John
Barnet, Susan
O'hagan, Derek
Barnet, Susan
O'hagan, Derek
Application Number:
JP2004543559A
Publication Date:
January 19, 2006
Filing Date:
October 07, 2003
Export Citation:
Assignee:
Chiron Corporation
International Classes:
A61K48/00; A61K35/76; A61K39/00; A61K39/21; A61K39/39; A61K47/34; A61P31/18; A61P37/04; C07H21/04; C07K14/16; C12N15/00; C12N15/09; C12N15/87; C12P21/02; C12P21/06; C12Q1/70; A61K
Other References:
JPN6009066437; Ｏ'ＨＡＧＡＮ，Ｄ． ｅｔ ａｌ: 'Ｉｎｄｕｃｔｉｏｎ ｏｆ ｐｏｔｅｎｔ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅｓ ｂｙ ｃａｔｉｏｎｉｃ ｍｉｃｒｏｐａｒｔｉｃｌｅｓ ｗｉｔｈ ａｄｓｏｒｂｅｄ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．１９, 2001, ｐ．９０３７-４３
JPN6009066434; ＳＲＩＶＡＳＴＡＶＡ，Ｉ．Ｋ． ｅｔ ａｌ: 'Ｐｕｒｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｏｌｉｇｏｍｅｒｉｃ ｅｎｖｅｌｏｐｅ ｇｌｙｃｏｐｒｏｔｅｉｎ ｆｒｏｍ ａ ｐｒｉｍａｒｙ Ｒ５ ｓｕｂｔｙｐｅ Ｂ ｈｕ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７６， Ｎｏ．６, 2002, ｐ．２８３５-４７
JPN6010070600; ＣＨＥＲＰＥＬＩＳ，Ｓ． ｅｔ ａｌ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｗｉｔｈ ｔｈｅ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ １ ＳＦ１６２ＤｅｌｔａＶ２ ｅｎｖｅｌｏｐｅ ｅｌｉｃｉｔｓ ｉｍｍｕｎｅ ｒｅ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．３, 2001, ｐ．１５４７-５０
JPN6009066437; Ｏ'ＨＡＧＡＮ，Ｄ． ｅｔ ａｌ: 'Ｉｎｄｕｃｔｉｏｎ ｏｆ ｐｏｔｅｎｔ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅｓ ｂｙ ｃａｔｉｏｎｉｃ ｍｉｃｒｏｐａｒｔｉｃｌｅｓ ｗｉｔｈ ａｄｓｏｒｂｅｄ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．１９, 2001, ｐ．９０３７-４３
JPN6009066434; ＳＲＩＶＡＳＴＡＶＡ，Ｉ．Ｋ． ｅｔ ａｌ: 'Ｐｕｒｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｏｌｉｇｏｍｅｒｉｃ ｅｎｖｅｌｏｐｅ ｇｌｙｃｏｐｒｏｔｅｉｎ ｆｒｏｍ ａ ｐｒｉｍａｒｙ Ｒ５ ｓｕｂｔｙｐｅ Ｂ ｈｕ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７６， Ｎｏ．６, 2002, ｐ．２８３５-４７
JPN6010070600; ＣＨＥＲＰＥＬＩＳ，Ｓ． ｅｔ ａｌ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｗｉｔｈ ｔｈｅ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ １ ＳＦ１６２ＤｅｌｔａＶ２ ｅｎｖｅｌｏｐｅ ｅｌｉｃｉｔｓ ｉｍｍｕｎｅ ｒｅ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．３, 2001, ｐ．１５４７-５０
JPN6009066434; ＳＲＩＶＡＳＴＡＶＡ，Ｉ．Ｋ． ｅｔ ａｌ: 'Ｐｕｒｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｏｌｉｇｏｍｅｒｉｃ ｅｎｖｅｌｏｐｅ ｇｌｙｃｏｐｒｏｔｅｉｎ ｆｒｏｍ ａ ｐｒｉｍａｒｙ Ｒ５ ｓｕｂｔｙｐｅ Ｂ ｈｕ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７６， Ｎｏ．６, 2002, ｐ．２８３５-４７
JPN6010070600; ＣＨＥＲＰＥＬＩＳ，Ｓ． ｅｔ ａｌ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｗｉｔｈ ｔｈｅ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ １ ＳＦ１６２ＤｅｌｔａＶ２ ｅｎｖｅｌｏｐｅ ｅｌｉｃｉｔｓ ｉｍｍｕｎｅ ｒｅ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．３, 2001, ｐ．１５４７-５０
JPN6009066437; Ｏ'ＨＡＧＡＮ，Ｄ． ｅｔ ａｌ: 'Ｉｎｄｕｃｔｉｏｎ ｏｆ ｐｏｔｅｎｔ ｉｍｍｕｎｅ ｒｅｓｐｏｎｓｅｓ ｂｙ ｃａｔｉｏｎｉｃ ｍｉｃｒｏｐａｒｔｉｃｌｅｓ ｗｉｔｈ ａｄｓｏｒｂｅｄ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．１９, 2001, ｐ．９０３７-４３
JPN6009066434; ＳＲＩＶＡＳＴＡＶＡ，Ｉ．Ｋ． ｅｔ ａｌ: 'Ｐｕｒｉｆｉｃａｔｉｏｎ ａｎｄ ｃｈａｒａｃｔｅｒｉｚａｔｉｏｎ ｏｆ ｏｌｉｇｏｍｅｒｉｃ ｅｎｖｅｌｏｐｅ ｇｌｙｃｏｐｒｏｔｅｉｎ ｆｒｏｍ ａ ｐｒｉｍａｒｙ Ｒ５ ｓｕｂｔｙｐｅ Ｂ ｈｕ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７６， Ｎｏ．６, 2002, ｐ．２８３５-４７
JPN6010070600; ＣＨＥＲＰＥＬＩＳ，Ｓ． ｅｔ ａｌ: 'ＤＮＡ ｖａｃｃｉｎａｔｉｏｎ ｗｉｔｈ ｔｈｅ ｈｕｍａｎ ｉｍｍｕｎｏｄｅｆｉｃｉｅｎｃｙ ｖｉｒｕｓ ｔｙｐｅ １ ＳＦ１６２ＤｅｌｔａＶ２ ｅｎｖｅｌｏｐｅ ｅｌｉｃｉｔｓ ｉｍｍｕｎｅ ｒｅ' Ｊ Ｖｉｒｏｌ Ｖｏｌ．７５， Ｎｏ．３, 2001, ｐ．１５４７-５０
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita