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Title:
L型カルシウムチャンネルを遮断し、かつホスホジエステラーゼ3型活性を阻害する同時能力を有するジヒドロピリジン化合物
Document Type and Number:
Japanese Patent JP2006504738
Kind Code:
A
Abstract:
The present invention provides compounds that possess inhibitory activity against PDE-3 and L-type calcium channels. The present invention further provides pharmaceutical compositions comprising such compounds and methods of using such compounds for treating cardiovascular disease, stroke, epilepsy, ophthalmic disorder or migraine.

Inventors:
Hamilton, Gregory, Es.
Leighton, harry, jefferson
Application Number:
JP2004543386A
Publication Date:
February 09, 2006
Filing Date:
October 07, 2003
Export Citation:
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Assignee:
Artesian Therapeutic, Incorporated
International Classes:
C07D401/12; A61K31/4709; A61K31/519; A61P3/14; A61P9/00; A61P9/04; A61P9/06; A61P9/12; A61P25/06; A61P25/08; A61P27/02; C07D211/90; C07D213/85; C07D237/04; C07D401/04; C07D487/04
Foreign References:
EP0287867A11988-10-26
US5344944A1994-09-06
EP0287866A11988-10-26
EP0185964A21986-07-02
US4898865A1990-02-06
US5100892A1992-03-31
EP0503079A11992-09-16
US4564619A1986-01-14
US4876255A1989-10-24
EP0189254A11986-07-30
EP0116769A11984-08-29
EP0132375A21985-01-30
EP0287867A11988-10-26
US5344944A1994-09-06
EP0287866A11988-10-26
EP0185964A21986-07-02
US4898865A1990-02-06
US5100892A1992-03-31
EP0503079A11992-09-16
US4564619A1986-01-14
US4876255A1989-10-24
EP0189254A11986-07-30
EP0116769A11984-08-29
EP0132375A21985-01-30
Other References:
JPN5005008896, Ｄ　ＡＬＫＥＲ, ＪＯＵＲＮＡＬ　ＯＦ　ＭＥＤＩＣＩＮＡＬ　ＣＨＥＭＩＳＴＲＹ, 1990, Ｖ３３, Ｐ５８５−５９１
JPN5005008897, ＲＵＭＰ　Ａ　Ｆ　Ｅ, ＧＥＮＥＲＡＬ　ＰＨＡＲＭＡＣＯＬＯＧＹ, 1995, Ｖ２６　Ｎ３, Ｐ６０３−６１１, GB, ＰＥＲＧＡＭＯＮ　ＰＲＥＳＳ
Attorney, Agent or Firm:
Hiroshi Kobayashi
Eiji Katayama
Junko Kobayashi
Norio Omori



 
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