Title:
非ヌクレオシド逆転写酵素インヒビター
Document Type and Number:
Japanese Patent JP2006505532
Kind Code:
A
Abstract:
Compounds represented by formula 1: wherein R1 is H, halogen, (C1-4)alkyl, O(C1-4)alkyl, and haloalkyl; R2 is H or methyl; R3 is H or (C1-4)alkyl; R4 is H or (C1-4)alkyl; R5 is (C1-4)alkyl, (C1-4)alkyl(C3-7)cyclo-alkyl or (C3-7)cycloalkyl; and W is a fused phenyl-5 or 6-membered heterocycle having one or two heteroatoms selected from N or S; or W is phenyl, 1,1'-biphenyl, 2,3-dihydro-1H-indene, 1,2,3,4-tetrahydronaphthyl, or naphthyl; said W being optionally substituted with (C1-4)alkyl, which in turn can be optionally substituted with a carboxy or (C1-4)alkoxycarbonyl, or a salt or ester thereof. The compounds have inhibitory activity against Wild Type, single and double mutant strains of HIV.
Inventors:
Joachim Christian
O'Milla Jeffrey
Simone Bruno
Oglevy William W
Desire Robert
O'Milla Jeffrey
Simone Bruno
Oglevy William W
Desire Robert
Application Number:
JP2004536726A
Publication Date:
February 16, 2006
Filing Date:
September 15, 2003
Export Citation:
Assignee:
Boehringer Ingelheim (Canada) Limited
International Classes:
C07D471/22; A61K31/551; A61P31/18; A61P43/00
Attorney, Agent or Firm:
Sadao Kumakura
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama
Nobuo Ogawa
Atsushi Hakoda
Kenji Asai
Koji Hirayama