Title:
生分解性トリブロックコポリマー、その合成方法、ならびにそれから作製されるヒドロゲルおよび生体材料
Document Type and Number:
Japanese Patent JP2006506335
Kind Code:
A
Abstract:
A drug delivery system that includes a hydrogel formed from cyclodextrin and an amphiphilic copolymer that includes an A polymer block comprising a poly(alkylene oxide) and a B polymer block comprising a poly(hydroxyalkanoate), and a therapeutically effective amount of at least one therapeutic agent intimately contained within the hydrogel. In one preferred embodiment of the invention, the A polymer block is poly(ethylene oxide) (PEO) and the B polymer block is poly[(R)-3-hydroxybutyrate] (PHB), and the copolymer is the triblock ABA copolymer PEO-PHB-PEO. A method of synthesizing the amphiphilic triblock copolymer is also provided.
Inventors:
Lee, Jun
Lee, shoe
Knee, shipping
Leon, Cam W.
Lee, shoe
Knee, shipping
Leon, Cam W.
Application Number:
JP2004523596A
Publication Date:
February 23, 2006
Filing Date:
July 18, 2003
Export Citation:
Assignee:
Omeros Corporation
Institute of Materials Research and Engineering
Institute of Materials Research and Engineering
International Classes:
A61K47/40; A61F2/00; A61K9/00; A61K9/06; A61K9/08; A61K9/51; A61K38/00; A61K47/32; A61K47/34; A61K47/48; A61L27/00; A61L27/34; A61L27/52; A61L27/54; A61L29/00; A61L31/00; A61L31/10; A61L31/14; A61L31/16; A61P43/00; C08G81/00; C08L5/16; C08L67/00
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita
Takaaki Yasumura
Natsuki Morishita