Title:
標的化された二本鎖RNA媒介による殺細胞
Document Type and Number:
Japanese Patent JP2006506433
Kind Code:
A
Abstract:
A method of killing a specific target cell/tissue is disclosed. The method comprises exposing the specific target cell/tissue to a composition-of-matter which comprises a double stranded RNA molecule associated with a targeting moiety selected capable of targeting to the specific target cell/tissue, thereby killing the specific target cell/tissue.
Inventors:
Seer, Alexei
Levitzky, Alexander
Levitzky, Alexander
Application Number:
JP2004553056A
Publication Date:
February 23, 2006
Filing Date:
November 12, 2003
Export Citation:
Assignee:
Issam Research Development Company of the Hebrew University of Jerusalem
International Classes:
A61K31/713; A61K31/07; A61K39/395; A61K47/48; A61K48/00; A61P25/00; A61P35/00; A61P35/04; A61P43/00; C07H21/02; C07K14/435
Other References:
JPN6010012863, ＳＡＬＡＺＡＲ，Ａ．Ｍ． ｅｔ ａｌ, "Ｌｏｎｇ−ｔｅｒｍ ｔｒｅａｔｍｅｎｔ ｏｆ ｍａｌｉｇｎａｎｔ ｇｌｉｏｍａｓ ｗｉｔｈ ｉｎｔｒａｍｕｓｃｕｌａｒｌｙ ａｄｍｉｎｉｓｔｅｒｅｄ ｐｏｌｙｉｎｏｓｉｎｉｃ−ｐｏｌｙｃｙｔｉｄｙｌｉ", Ｎｅｕｒｏｓｕｒｇｅｒｙ, 1996, Ｖｏｌ．３８， Ｎｏ．６, ｐ．１０９６−１０３
JPN7010000702, ＣＨＡＣＫＯ，Ｍ．Ｓ． ｅｔ ａｌ, "Ｄｏｕｂｌｅ−ｓｔｒａｎｄｅｄ ｒｉｂｏｎｕｃｌｅｉｃ ａｃｉｄ ｄｅｃｒｅａｓｅｓ ｃ６ ｒａｔ ｇｌｉｏｍａ ｃｅｌｌ ｐｒｏｌｉｆｅｒａｔｉｏｎ ｉｎ ｐａｒｔ ｂｙ ａｃｔｉｖａｔｉｎｇ ｐｒ", Ｅｎｄｏｃｒｉｎｏｌｏｇｙ, 200206, Ｖｏｌ．１４３， Ｎｏ．６, ｐ．２１４４−５４
JPN7010000703, ＬＩＵ，Ｄ． ｅｔ ａｌ, "Ｄｏｕｂｌｅ−ｓｔｒａｎｄｅｄ ｒｉｂｏｎｕｃｌｅｉｃ ａｃｉｄ （ＲＮＡ） ｉｎｄｕｃｅｓ ｂｅｔａ−ｃｅｌｌ Ｆａｓ ｍｅｓｓｅｎｇｅｒ ＲＮＡ ｅｘｐｒｅｓｓｉｏｎ ａｎｄ ｉｎｃｒｅａｓｅｓ", Ｅｎｄｏｃｒｉｎｏｌｏｇｙ, 2001, Ｖｏｌ．１４２， Ｎｏ．６, ｐ．２５９３−９
JPN7010000704, ＢＬＥＳＳＩＮＧ，Ｔ． ｅｔ ａｌ, "Ｄｉｆｆｅｒｅｎｔ ｓｔｒａｔｅｇｉｅｓ ｆｏｒ ｆｏｒｍａｔｉｏｎ ｏｆ ｐｅｇｙｌａｔｅｄ ＥＧＦ−ｃｏｎｊｕｇａｔｅｄ ＰＥＩ／ＤＮＡ ｃｏｍｐｌｅｘｅｓ ｆｏｒ ｔａｒｇｅｔｅｄ ｇｅｎｅ ｄ", Ｂｉｏｃｏｎｊｕｇ Ｃｈｅｍ, 2001, Ｖｏｌ．１２， Ｎｏ．４, ｐ．５２９−３７
JPN5005011575, ＳＯＳＮＯＷＳＫＩ, ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 1996, Ｖ２７１ Ｎ５２, Ｐ３３６４７−３３６５３
JPN5005011574, ＯＧＲＩＳ, ＡＡＰＳ ＰＨＡＲＭＳＣＩ, 2001, Ｖ３ Ｎ３, Ｐ１−１１
JPN7010000706, ＣＯＬＬＩＮＳ，Ｖ．Ｐ． ｅｔ ａｌ, "Ｇｅｎｅ ａｎｄ ｃｈｒｏｍｏｓｏｍａｌ ａｌｔｅｒａｔｉｏｎｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｈｕｍａｎ ｇｌｉｏｍａｓ", ＦＡＳＥＢ Ｊ, 1993, Ｖｏｌ．７， Ｎｏ．１０, ｐ．９２６−３０
JPN7010000707, ＢＥＴＴＩＮＧＥＲ，Ｔ． ｅｔ ａｌ, "Ｐｅｐｔｉｄｅ−ｍｅｄｉａｔｅｄ ＲＮＡ ｄｅｌｉｖｅｒｙ： ａ ｎｏｖｅｌ ａｐｐｒｏａｃｈ ｆｏｒ ｅｎｈａｎｃｅｄ ｔｒａｎｓｆｅｃｔｉｏｎ ｏｆ ｐｒｉｍａｒｙ ａｎｄ ｐｏｓｔ−ｍｉｔｏｔｉ", Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓ, 2001, Ｖｏｌ．２９， Ｎｏ．１８, ｐ．３８８２−９１
JPN7010000702, ＣＨＡＣＫＯ，Ｍ．Ｓ． ｅｔ ａｌ, "Ｄｏｕｂｌｅ−ｓｔｒａｎｄｅｄ ｒｉｂｏｎｕｃｌｅｉｃ ａｃｉｄ ｄｅｃｒｅａｓｅｓ ｃ６ ｒａｔ ｇｌｉｏｍａ ｃｅｌｌ ｐｒｏｌｉｆｅｒａｔｉｏｎ ｉｎ ｐａｒｔ ｂｙ ａｃｔｉｖａｔｉｎｇ ｐｒ", Ｅｎｄｏｃｒｉｎｏｌｏｇｙ, 200206, Ｖｏｌ．１４３， Ｎｏ．６, ｐ．２１４４−５４
JPN7010000703, ＬＩＵ，Ｄ． ｅｔ ａｌ, "Ｄｏｕｂｌｅ−ｓｔｒａｎｄｅｄ ｒｉｂｏｎｕｃｌｅｉｃ ａｃｉｄ （ＲＮＡ） ｉｎｄｕｃｅｓ ｂｅｔａ−ｃｅｌｌ Ｆａｓ ｍｅｓｓｅｎｇｅｒ ＲＮＡ ｅｘｐｒｅｓｓｉｏｎ ａｎｄ ｉｎｃｒｅａｓｅｓ", Ｅｎｄｏｃｒｉｎｏｌｏｇｙ, 2001, Ｖｏｌ．１４２， Ｎｏ．６, ｐ．２５９３−９
JPN7010000704, ＢＬＥＳＳＩＮＧ，Ｔ． ｅｔ ａｌ, "Ｄｉｆｆｅｒｅｎｔ ｓｔｒａｔｅｇｉｅｓ ｆｏｒ ｆｏｒｍａｔｉｏｎ ｏｆ ｐｅｇｙｌａｔｅｄ ＥＧＦ−ｃｏｎｊｕｇａｔｅｄ ＰＥＩ／ＤＮＡ ｃｏｍｐｌｅｘｅｓ ｆｏｒ ｔａｒｇｅｔｅｄ ｇｅｎｅ ｄ", Ｂｉｏｃｏｎｊｕｇ Ｃｈｅｍ, 2001, Ｖｏｌ．１２， Ｎｏ．４, ｐ．５２９−３７
JPN5005011575, ＳＯＳＮＯＷＳＫＩ, ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＢＩＯＬＯＧＩＣＡＬ ＣＨＥＭＩＳＴＲＹ, 1996, Ｖ２７１ Ｎ５２, Ｐ３３６４７−３３６５３
JPN5005011574, ＯＧＲＩＳ, ＡＡＰＳ ＰＨＡＲＭＳＣＩ, 2001, Ｖ３ Ｎ３, Ｐ１−１１
JPN7010000706, ＣＯＬＬＩＮＳ，Ｖ．Ｐ． ｅｔ ａｌ, "Ｇｅｎｅ ａｎｄ ｃｈｒｏｍｏｓｏｍａｌ ａｌｔｅｒａｔｉｏｎｓ ａｓｓｏｃｉａｔｅｄ ｗｉｔｈ ｔｈｅ ｄｅｖｅｌｏｐｍｅｎｔ ｏｆ ｈｕｍａｎ ｇｌｉｏｍａｓ", ＦＡＳＥＢ Ｊ, 1993, Ｖｏｌ．７， Ｎｏ．１０, ｐ．９２６−３０
JPN7010000707, ＢＥＴＴＩＮＧＥＲ，Ｔ． ｅｔ ａｌ, "Ｐｅｐｔｉｄｅ−ｍｅｄｉａｔｅｄ ＲＮＡ ｄｅｌｉｖｅｒｙ： ａ ｎｏｖｅｌ ａｐｐｒｏａｃｈ ｆｏｒ ｅｎｈａｎｃｅｄ ｔｒａｎｓｆｅｃｔｉｏｎ ｏｆ ｐｒｉｍａｒｙ ａｎｄ ｐｏｓｔ−ｍｉｔｏｔｉ", Ｎｕｃｌｅｉｃ Ａｃｉｄｓ Ｒｅｓ, 2001, Ｖｏｌ．２９， Ｎｏ．１８, ｐ．３８８２−９１
Attorney, Agent or Firm:
Nobuaki Kazehaya
Noriko Asano
Noriko Asano