Title:
モルヒネへの心理的依存又は耐性を防止及び処置するのに有効成分としてベルベリンを含有する医薬組成物
Document Type and Number:
Japanese Patent JP2006506460
Kind Code:
A
Abstract:
Disclosed is a pharmaceutical composition for preventing and treating addiction to morphine or preventing and inhibiting the development of tolerance to the analgesic effects of morphine, containing berberine as an effective ingredient, wherein the berberine has an inhibitory effect versus psychological dependence on abused drugs such as morphine and the increase of spontaneous locomotor activity upon administration of the drugs, The pharmaceutical composition and a Coptis japonica plant extract of the present invention, which contain berberine, are highly effective in inhibiting the aforementioned symptoms of morphine addiction, and are thus useful for prevention and treatment of addiction to abused drugs such as morphine. In addition, the pharmaceutical composition additionally containing a pharmaceutical acceptable carrier can be applied to prevent and inhibit morphine tolerance caused by repeated administration of morphine, while not affecting the analgesic effects of morphine upon a single administration.
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Inventors:
Yang, Chun-Gong
Lee, Seok-young
Lee, Seok-young
Application Number:
JP2005501862A
Publication Date:
February 23, 2006
Filing Date:
October 27, 2003
Export Citation:
Assignee:
Sang Kyun Kwan University
International Classes:
A61K31/4375; A61P25/30; A61P25/36; C07D491/14
Domestic Patent References:
| JP2000264842A | 2000-09-26 | |||
| JPS5753404A | 1982-03-30 |
Attorney, Agent or Firm:
Takao Hamano
Morita Tetsuji
Teruichi Hirai
Morita Tetsuji
Teruichi Hirai