Title:
カスパーゼ活性化剤およびアポトーシス誘導剤としてのガンボジック酸誘導体および類似体
Document Type and Number:
Japanese Patent JP2006507227
Kind Code:
A
Abstract:
The present invention is directed to derivatives of gambogic acid and analogs thereof. Exemplary gambogic acid derivatives of the present invention include, among others, derivatives substituted in the C10 and C28 positions of gambogic acid. The present invention also relates to the discovery that certain preferred compounds of the present invention are activators of caspases and inducers of apoptosis. Therefore, the activators of caspases and inducers of apoptosis of this invention can be used to induce cell death in a variety of clinical conditions in which uncontrolled growth and spread of abnormal cells occurs.
Inventors:
Sten Ben
Sirisoma Nilansa Sudus
Kai Sui
Chang Han-Jung
Kashib Hatra Shairaja
Oris Christine Pea.
Dr. John A.
Sirisoma Nilansa Sudus
Kai Sui
Chang Han-Jung
Kashib Hatra Shairaja
Oris Christine Pea.
Dr. John A.
Application Number:
JP2004518157A
Publication Date:
March 02, 2006
Filing Date:
July 01, 2003
Export Citation:
Assignee:
Sightvia Inc.
International Classes:
C07D493/18; A61K31/352; A61K31/453; A61K31/496; A61K31/5377; A61K45/00; A61P17/00; A61P17/06; A61P29/00; A61P31/12; A61P35/00; A61P37/02; A61P39/00; A61P43/00; C07D493/20; C12N5/02
Foreign References:
| WO2000044216A2 | 2000-08-03 | |||
| WO2000045165A1 | 2000-08-03 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Kazunori Hashimoto
Koichi Niimi
Kazunori Hashimoto
Koichi Niimi
Previous Patent: 薬剤、化粧品、または食品組成物の抗酸化剤として使用可能なラクトン化...
Next Patent: 応答性の細胞、組織および器官を保護、回復ならびに増強するための組換...
Next Patent: 応答性の細胞、組織および器官を保護、回復ならびに増強するための組換...