Title:
3-プロペニルセファロスポリンDMF溶媒和物の調製方法
Document Type and Number:
Japanese Patent JP2006508093
Kind Code:
A
Abstract:
The present invention relates to an improved process for the preparation of cefprozil DMF solvate of formula (I), which is useful for the preparation of cefprozil, comprising: i) reacting a compound of formula (VIII) with acetaldehyde to produce a compound of formula (IX), ii) deesterifying the carboxy protecting group of the compound of formula (IX) using an acid to yield a compound of formula (X), iii) converting the compound of formula (X) to a compound of formula (XI), iv) neutralizing the compound of formula (XI) followed by enzymatic hydrolysis to produce an APCA of formula (V), v) silylating the APCA using a mixture of trimethylsilylchloride and hexamethyldisilazane to produce silylated APCA of formula (XII), and vi) condensing the silylated APCA with a mixed anhydride to produce the DMF solvate compound of formula (I).
Inventors:
Deshpande, Pandlang, Balwand
Cardangare, bausaheb, pandarinus
Guru Sammy, Kumar
Conda, Ramesh, Asmaram
Cardangare, bausaheb, pandarinus
Guru Sammy, Kumar
Conda, Ramesh, Asmaram
Application Number:
JP2004547840A
Publication Date:
March 09, 2006
Filing Date:
December 18, 2002
Export Citation:
Assignee:
ORCHID CHEMICALS & PHARMACEUTICALS LIMITED
International Classes:
C07D501/06; A61K31/545; A61P31/04; C07D501/00; C07D501/04; C07D501/12; C07D501/22
Attorney, Agent or Firm:
Ikeuchi, Sato & Partners