Title:
吸収されにくい極性薬物の経口用製剤
Document Type and Number:
Japanese Patent JP2006510656
Kind Code:
A
Abstract:
Disclosed herein is a pharmaceutical composition for oral absorption of polar drugs. The composition consists essentially of (a) at least one polar active substance having a bioavailability of less than 30% which is poorly absorptive through lipid membranes because of its high hydrophilicity and charged ion; (b) at least one organic alkalizing agent having an amino acid or polyol structure which shows alkalinity in aqueous solution and is ionically bonded to the polar active substance; and (c) at least one surfactant having a C6-18 fatty acid structure which has an HLB of 4 to 18. Alternatively, the composition consists essentially of (d) at least one organic alkalizing agent having the characteristics of both the organic alkalizing agent and the surfactant instead of the organic alkalizing agent and the surfactant. The composition enables polar active drugs to penetrate the gastro-intestinal membrane and oral dosage forms to be substituted for injections.
Inventors:
Hong Jung Il
Shin Hee Jung
Kim Min Hyo
Chemifa
Shin Hee Jung
Kim Min Hyo
Chemifa
Application Number:
JP2004558536A
Publication Date:
March 30, 2006
Filing Date:
December 10, 2003
Export Citation:
Assignee:
Chung Kung Dan Pharmaceutical Corporation
International Classes:
A61K47/48; A61K9/10; A61K9/16; A61K9/20; A61K31/546; A61K47/14
Attorney, Agent or Firm:
Norio Saeki