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Title:
化学療法剤および化学予防剤としての緑茶ポリフェノールのアナログ
Document Type and Number:
Japanese Patent JP2006510658
Kind Code:
A
Abstract:
Novel compounds useful as chemotherapeutic and chemopreventive agents are provided. The compounds are analogs of polyphenol catechins that occur in green tea, such as epigallocatichin-3-gallate (EGCG), and have the structure of formula (I) wherein R1 through R11 are defined herein. Preferred R4 moieties are selected from O, S, NH and CH2, and in exemplary compounds, R4 is O and R5 is a tri-substituted aroyloxy substituent, such as a 3,4,5-substituted benzoyloxy group. Pharmaceutical compositions are provided as well, as are methods of chemotherapy and chemoprevention.

Inventors:
Zaveri, Null Line
Chao, Wan-le
Ben Sari, Arlem
Application Number:
JP2004558631A
Publication Date:
March 30, 2006
Filing Date:
December 08, 2003
Export Citation:
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Assignee:
SRI INTERNATIONAL
International Classes:
C07D311/62; A61K9/20; A61K9/48; A61K31/353; A61P35/00
Domestic Patent References:
JP2001253879A2001-09-18
Foreign References:
US20020151582A12002-10-17
WO1999022728A11999-05-14
Attorney, Agent or Firm:
Hidesaku Yamamoto
Takaaki Yasumura
Natsuki Morishita



 
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