Title:
複素環式ケイ素化合物、ならびにGnRH(ゴナドトロピン放出ホルモン)と関係のある疾患または状態の治療におけるその使用
Document Type and Number:
Japanese Patent JP2006510725
Kind Code:
A
Abstract:
A compound of formula (I) wherein one of X and Y is silicon, and the other is carbon or silicon; Z is oxygen, sulphur or -N(R)-, wherein R is hydrogen or alkyl; R1 is hydrogen, halogen, alkyl, alkenyl, alkynyl, alkoxy or cycloalkyl; and R2 is alkyl, alkenyl, alkynyl, cycloalkyl, heterocycloalkyl, aryl, heteroaryl, -alkyl-cycloalkyl, -alkyl-heterocycloalkyl, -alkyl-aryl or -alkyl-heteroaryl; or a pharmaceutically acceptable salt thereof. The compounds are used in the manufacture of a medicament for the treatment or prevention of a disease or condition associated with GnRH (gonadotropin-releasing hormone), e.g. for the treatment or prevention of progression of cancer (e.g. leukaemia therapy), of a fertility disorder, of HIV infection or AIDS, of Alzheimer's disease of fibrosis, of endometriosis, of uterine fibroids or of uterine leiomyom
Inventors:
John Gary Montana
Ian Fleming
Reinhold Tucke
Jurgen Dice
Ian Fleming
Reinhold Tucke
Jurgen Dice
Application Number:
JP2004570306A
Publication Date:
March 30, 2006
Filing Date:
November 19, 2003
Export Citation:
Assignee:
Paradigm Therapeutics Limited
International Classes:
C07F7/10; A61K31/695; A61P5/04; A61P15/00; A61P15/08; A61P19/04; A61P21/00; A61P25/28; A61P31/18; A61P35/00; A61P35/02; C07F7/08
Attorney, Agent or Firm:
Masatake Shiga
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro
Takashi Watanabe
Yasuhiko Murayama
Shinya Mitsuhiro