Title:
アナンダミド加水分解の遮断による不安の調節
Document Type and Number:
Japanese Patent JP2006511484
Kind Code:
A
Abstract:
Fatty acid amide hydrolase inhibitors of the Formula: are provided wherein X is NH, CH2, O, or S; Q is O or S; Z is O or N; R is an aromatic moiety selected from the group consisting of substituted or unsubstituted aryl; substituted or unsubstituted biphenylyl, substituted or unsubstituted naphthyl, and substituted or unsubstituted phenyl; substituted or unsubstituted terphenylyl; substituted or unsubstituted cycloalkyl, heteroaryl, or alkyl; and R1 and R2 are independently selected from the group consisting of H, substituted or unsubstituted alkyl, substituted or unsubstituted heteroalkyl, and substituted or unsubstituted phenyl, substituted or unsubstituted biphenylyl, substituted or unsubstituted aryl, and substituted or unsubstituted heteroaryl; with the proviso that if Z is O, one of R1 and R2 is absent, and that if Z is N, optionally R1 and R2 may optionally be taken together to form a substituted or unsubstituted N-heterocycle or substituted or unsubstituted heteroaryl with the N atom to which they are each attached. Pharmaceutical compositions comprising the compounds of Formula I and methods of using them to inhibit FAAH and/or treat appetite disorders, glaucoma, pain, insomnia, and neurological and psychological disorders including anxiety disorders, epilepsy, and depression are provided.
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Inventors:
Piomel daniel
Duranty Andrea
Tontini Andrea
Mall Marco
Targia Georgeo
Duranty Andrea
Tontini Andrea
Mall Marco
Targia Georgeo
Application Number:
JP2004543510A
Publication Date:
April 06, 2006
Filing Date:
October 07, 2003
Export Citation:
Assignee:
The Legends of the University of California
Universita Degli Study di Urbino
Universita Degli Study Di Palma
Universita Degli Study di Urbino
Universita Degli Study Di Palma
International Classes:
C07C271/56; A61K31/165; A61K31/17; A61K31/27; A61K31/343; A61K31/40; A61K31/404; A61K31/407; A61K31/47; A61P25/00; A61P25/02; A61P25/20; A61P25/22; A61P25/24; A61P27/06; A61P43/00; C07C271/00; C07C271/44; C07C271/58; C07C275/54; C07C311/29; C07C333/06; C07C333/22; C07C335/16; C07D209/08; C07D215/08; C07D295/20; C07D307/79; C07D403/04; C07D403/06; C07D403/12; C07D405/04; C07D405/06; C07D405/12; C07D409/04; C07D409/06; C07D409/12; C07D487/04
Domestic Patent References:
| JP2005516986A | 2005-06-09 | |||
| JP2004532229A | 2004-10-21 | |||
| JP2005539045A | 2005-12-22 | |||
| JP2004505958A | 2004-02-26 | |||
| JPH0892167A | 1996-04-09 | |||
| JPS57112363A | 1982-07-13 | |||
| JPH10512848A | 1998-12-08 |
Foreign References:
| US5476944A | 1995-12-19 | |||
| EP1231212A1 | 2002-08-14 | |||
| US5112859A | 1992-05-12 | |||
| US6531506B1 | 2003-03-11 | |||
| US4987233A | 1991-01-22 | |||
| US2776197A | 1957-01-01 |
Attorney, Agent or Firm:
Hatsushi Shimizu
Koichi Niimi
Koichi Niimi